dbPTM

MLC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MLC1_HUMAN
UniProt AC	Q15049
Protein Name	Membrane protein MLC1
Gene Name	MLC1
Organism	Homo sapiens (Human).
Sequence Length	377
Subcellular Localization	Membrane Multi-pass membrane protein . Cell membrane . Cytoplasm, perinuclear region . Endoplasmic reticulum .
Protein Description	Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx..
Protein Sequence	MTQEPFREELAYDRMPTLERGRQDPASYAPDAKPSDLQLSKRLPPCFSHKTWVFSVLMGSCLLVTSGFSLYLGNVFPAEMDYLRCAAGSCIPSAIVSFTVSRRNANVIPNFQILFVSTFAVTTTCLIWFGCKLVLNPSAININFNLILLLLLELLMAATVIIAARSSEEDCKKKKGSMSDSANILDEVPFPARVLKSYSVVEVIAGISAVLGGIIALNVDDSVSGPHLSVTFFWILVACFPSAIASHVAAECPSKCLVEVLIAISSLTSPLLFTASGYLSFSIMRIVEMFKDYPPAIKPSYDVLLLLLLLVLLLQAGLNTGTAIQCVRFKVSARLQGASWDTQNGPQERLAGEVARSPLKEFDKEKAWRAVVVQMAQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PFREELAYDRMPTLE CHHHHHHHCCCCCHH	19.39	28176486
17	Phosphorylation	LAYDRMPTLERGRQD HHHCCCCCHHHCCCC	31.72	22115753
27	Phosphorylation	RGRQDPASYAPDAKP HCCCCHHHHCCCCCH	27.50	21552520
28	Phosphorylation	GRQDPASYAPDAKPS CCCCHHHHCCCCCHH	25.02	21552520
33	Ubiquitination	ASYAPDAKPSDLQLS HHHCCCCCHHHCCHH	53.05	-
35	Phosphorylation	YAPDAKPSDLQLSKR HCCCCCHHHCCHHHC	50.69	25307156
41	Ubiquitination	PSDLQLSKRLPPCFS HHHCCHHHCCCCCCC	67.55	-
65	Phosphorylation	MGSCLLVTSGFSLYL HCHHEEECCCCCEEC	24.09	22817900
175	Ubiquitination	EEDCKKKKGSMSDSA HHHHHHHCCCCCCCC	66.16	-
177	Phosphorylation	DCKKKKGSMSDSANI HHHHHCCCCCCCCHH	24.80	23401153
179	Phosphorylation	KKKKGSMSDSANILD HHHCCCCCCCCHHHH	30.06	24076635
181	Phosphorylation	KKGSMSDSANILDEV HCCCCCCCCHHHHCC	18.86	23401153
197	Phosphorylation	FPARVLKSYSVVEVI CCHHHHCCCCHHHHH	20.62	22817900
339	Phosphorylation	SARLQGASWDTQNGP EEECCCCCCCCCCCH	32.10	25307156
357	Phosphorylation	LAGEVARSPLKEFDK HHHHHHHCCCHHCCH	25.50	23401153
360	Ubiquitination	EVARSPLKEFDKEKA HHHHCCCHHCCHHHH	60.77	21890473
360	Ubiquitination	EVARSPLKEFDKEKA HHHHCCCHHCCHHHH	60.77	21890473
366	Ubiquitination	LKEFDKEKAWRAVVV CHHCCHHHHHHHHHH	60.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MLC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MLC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MLC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCJ10_HUMAN	KCNJ10	physical	19931615
SNTA1_HUMAN	SNTA1	physical	19931615
DTNA_HUMAN	DTNA	physical	19931615
DTNB_HUMAN	DTNB	physical	19931615
CAV1_HUMAN	CAV1	physical	19931615
TBA1A_RAT	Tuba1a	physical	19931615
KCJ10_RAT	Kcnj10	physical	19931615
DTNB_RAT	Dtnb	physical	19931615
CAV2_RAT	Cav2	physical	19931615
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924

Drug and Disease Associations

Kegg Disease
H00875	Megalencephalic leukoencephalopathy with subcortical cysts (MLC)
OMIM Disease
604004	Leukoencephalopathy, megalencephalic, with subcortical cysts, 1 (MLC1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MLC1_HUMAN

Related Literatures of Post-Translational Modification