dbPTM

KCJ10_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCJ10_RAT
UniProt AC	P49655
Protein Name	ATP-sensitive inward rectifier potassium channel 10
Gene Name	Kcnj10
Organism	Rattus norvegicus (Rat).
Sequence Length	379
Subcellular Localization	Membrane Multi-pass membrane protein . Basolateral cell membrane . In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
Protein Description	May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (By similarity)..
Protein Sequence	MTSVAKVYYSQTTQTESRPLVAPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELGPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVAYHNGKLCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYVADFSLFDQVVKVASPGGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
6	Ubiquitination	--MTSVAKVYYSQTT --CCCEEEEEEEECC	-
8	Phosphorylation	MTSVAKVYYSQTTQT CCCEEEEEEEECCCC	-
9	Phosphorylation	TSVAKVYYSQTTQTE CCEEEEEEEECCCCC	-
224	Ubiquitination	LLQTHQTKEGENIRL HHHEECCCCCCCEEE	-
338	Phosphorylation	DQVVKVASPGGLRDS CEEEECCCCCCCCCC	25403869
354	Ubiquitination	VRYGDPEKLKLEESL CCCCCHHHCCHHHHH	-
356	Ubiquitination	YGDPEKLKLEESLRE CCCHHHCCHHHHHHH	-
367	Ubiquitination	SLREQAEKEGSALSV HHHHHHHHHCCCEEE	-
370	Phosphorylation	EQAEKEGSALSVRIS HHHHHHCCCEEEEEE	22673903
373	Phosphorylation	EKEGSALSVRISNV- HHHCCCEEEEEECC-	22673903
377	Phosphorylation	SALSVRISNV----- CCEEEEEECC-----	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
377	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KCJ10_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCJ10_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of KCJ10_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KCJ10_RAT

Related Literatures of Post-Translational Modification