MATN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MATN4_HUMAN
• UniProt AC: O95460
• Protein Name: Matrilin-4
• Gene Name: MATN4
• Organism: Homo sapiens (Human).
• Sequence Length: 622
• Subcellular Localization: Secreted.
• Protein Description: Major component of the extracellular matrix of cartilage..
• Protein Sequence: MRGLLCWPVLLLLLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRLCGKDQCAEGGHGCQHQCVNAWAMFHCTCNPGYKLAADNKSCLAIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDLENQLANQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	LVFVIDSSRSVRPFE EEEEEECCCCCCCCC	25.48	-
44	Phosphorylation	FVIDSSRSVRPFEFE EEEECCCCCCCCCHH	25.15	-
69	N-linked_Glycosylation	RGLNVGPNATRVGVI HCCCCCCCCCEEEEE	48.27	UniProtKB CARBOHYD
79	Phosphorylation	RVGVIQYSSQVQSVF EEEEEEECHHHEEEC	9.64	20044836
84	Phosphorylation	QYSSQVQSVFPLRAF EECHHHEEECCCCCC	27.20	24719451
92	Phosphorylation	VFPLRAFSRREDMER ECCCCCCCCHHHHHH	29.46	28355574
111	Phosphorylation	LVPLAQGTMTGLAIQ HHHHHHCCHHHHHHH	10.24	22210691
113	Phosphorylation	PLAQGTMTGLAIQYA HHHHCCHHHHHHHHH	28.96	26074081
119	Phosphorylation	MTGLAIQYAMNVAFS HHHHHHHHHHHHHHH	11.16	26074081
126	Phosphorylation	YAMNVAFSVAEGARP HHHHHHHHHHCCCCC	15.64	26074081
251	N-linked_Glycosylation	GYKLAADNKSCLAID CCCEECCCCCEEEEE	33.15	UniProtKB CARBOHYD
305	N-linked_Glycosylation	IDYCSFGNHSCQHEC EEEECCCCCCCCCEE	23.14	UniProtKB CARBOHYD
349	Phosphorylation	CNGVDHGCEFQCVSE HCCCCCCCEEEECCC	4.20	-
431	Phosphorylation	RVGLVQFSSRVRTEF EEEEEEECCCCCCCC	10.51	22817900
593	Phosphorylation	LVEFQGRTLGALESL CEEECCCHHHHHHHH	36.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MATN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MATN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MATN4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPE39_HUMAN	VIPAS39	physical	28514442
VP33B_HUMAN	VPS33B	physical	28514442
CILP2_HUMAN	CILP2	physical	28514442
MATN1_HUMAN	MATN1	physical	28514442
NACC1_HUMAN	NACC1	physical	28514442
BCS1_HUMAN	BCS1L	physical	28514442
ARGI2_HUMAN	ARG2	physical	28514442
ZMYM2_HUMAN	ZMYM2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.