MATN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MATN1_HUMAN
• UniProt AC: P21941
• Protein Name: Cartilage matrix protein
• Gene Name: MATN1
• Organism: Homo sapiens (Human).
• Sequence Length: 496
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen..
• Protein Sequence: MRVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILENTVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRVLSGTSLMLC ---CCCCCHHHHHHH	36.85	24043423
7	Phosphorylation	-MRVLSGTSLMLCSL -CCCCCHHHHHHHHH	18.47	24043423
8	Phosphorylation	MRVLSGTSLMLCSLL CCCCCHHHHHHHHHH	18.46	24043423
13	Phosphorylation	GTSLMLCSLLLLLQA HHHHHHHHHHHHHHH	20.35	24043423
23	Phosphorylation	LLLQALCSPGLAPQS HHHHHHCCCCCCCCC	23.89	24043423
30	Phosphorylation	SPGLAPQSRGHLCRT CCCCCCCCCCCCCCC	38.89	24043423
76	N-linked_Glycosylation	ESLDVGPNATRVGMV HHCCCCCCCEEEEEE	48.27	UniProtKB CARBOHYD
153	Phosphorylation	SKVVIVVTDGRPQDS CEEEEEEECCCCCCC	23.11	24719451
352	Phosphorylation	MSYMEKGTMTGAALK CCHHHHCCCCHHHHH	23.72	-
354	Phosphorylation	YMEKGTMTGAALKYL HHHHCCCCHHHHHHH	24.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MATN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MATN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MATN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MATN2_HUMAN	MATN2	physical	11896063
MATN3_HUMAN	MATN3	physical	11896063
MATN4_HUMAN	MATN4	physical	11896063

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.