| UniProt ID | MATN3_HUMAN | |
|---|---|---|
| UniProt AC | O15232 | |
| Protein Name | Matrilin-3 | |
| Gene Name | MATN3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 486 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.. | |
| Protein Sequence | MPRPAPARRLPGLLLLLWPLLLLPSAAPDPVARPGFRRLETRGPGGSPGRRPSPAAPDGAPASGTSEPGRARGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSRIIDTLDIGPADTRVAVVNYASTVKIEFQLQAYTDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGAREPSSNIPKVAIIVTDGRPQDQVNEVAARAQASGIELYAVGVDRADMASLKMMASEPLEEHVFYVETYGVIEKLSSRFQETFCALDPCVLGTHQCQHVCISDGEGKHHCECSQGYTLNADKKTCSALDRCALNTHGCEHICVNDRSGSYHCECYEGYTLNEDRKTCSAQDKCALGTHGCQHICVNDRTGSHHCECYEGYTLNADKKTCSVRDKCALGSHGCQHICVSDGAASYHCDCYPGYTLNEDKKTCSATEEARRLVSTEDACGCEATLAFQDKVSSYLQRLNTKLDDILEKLKINEYGQIHR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 41 | Phosphorylation | PGFRRLETRGPGGSP CCCCCCCCCCCCCCC | 45.58 | 22985185 | |
| 53 | Phosphorylation | GSPGRRPSPAAPDGA CCCCCCCCCCCCCCC | 25.92 | 26091039 | |
| 53 | O-linked_Glycosylation | GSPGRRPSPAAPDGA CCCCCCCCCCCCCCC | 25.92 | 55826837 | |
| 63 | O-linked_Glycosylation | APDGAPASGTSEPGR CCCCCCCCCCCCCCC | 41.36 | OGP | |
| 65 | O-linked_Glycosylation | DGAPASGTSEPGRAR CCCCCCCCCCCCCCC | 27.67 | 46249171 | |
| 65 | Phosphorylation | DGAPASGTSEPGRAR CCCCCCCCCCCCCCC | 27.67 | - | |
| 93 | Phosphorylation | FIIDSSRSVRPLEFT EEEECCCCCCCCCHH | 25.15 | 22817900 | |
| 112 | Phosphorylation | FVSRIIDTLDIGPAD HHHHHHHHCCCCCCC | 18.87 | - | |
| 120 | Phosphorylation | LDIGPADTRVAVVNY CCCCCCCCEEEEEEC | 29.20 | - | |
| 154 | Phosphorylation | KQAVGRITPLSTGTM HHHHCCCCCCCCCCC | 19.47 | - | |
| 175 | Phosphorylation | TAMDEAFTVEAGARE HHHHHCEEECCCCCC | 25.20 | - | |
| 184 | Phosphorylation | EAGAREPSSNIPKVA CCCCCCCCCCCCEEE | 31.12 | - | |
| 198 | Methylation | AIIVTDGRPQDQVNE EEEEECCCCHHHHHH | 28.63 | - | |
| 295 | Phosphorylation | HCECSQGYTLNADKK EEEECCCEEECCCHH | 10.62 | 17053785 | |
| 326 | Phosphorylation | HICVNDRSGSYHCEC EEEECCCCCCEEEEE | 34.65 | 26552605 | |
| 328 | Phosphorylation | CVNDRSGSYHCECYE EECCCCCCEEEEEEC | 16.98 | 26552605 | |
| 329 | Phosphorylation | VNDRSGSYHCECYEG ECCCCCCEEEEEECC | 17.64 | 26552605 | |
| 334 | Phosphorylation | GSYHCECYEGYTLNE CCEEEEEECCEEECC | 7.06 | 26552605 | |
| 337 | Phosphorylation | HCECYEGYTLNEDRK EEEEECCEEECCCCC | 8.98 | 26552605 | |
| 338 | Phosphorylation | CECYEGYTLNEDRKT EEEECCEEECCCCCC | 33.68 | 26552605 | |
| 407 | Phosphorylation | GCQHICVSDGAASYH CCCEEEECCCCCEEE | 26.39 | - | |
| 441 | Phosphorylation | EEARRLVSTEDACGC HHHHHHHCHHHCCCC | 30.58 | 26091039 | |
| 442 | Phosphorylation | EARRLVSTEDACGCE HHHHHHCHHHCCCCC | 30.33 | 16287128 | |
| 442 | O-linked_Glycosylation | EARRLVSTEDACGCE HHHHHHCHHHCCCCC | 30.33 | OGP | |
| 459 | Phosphorylation | LAFQDKVSSYLQRLN HHHHHHHHHHHHHHH | 21.00 | - |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MATN3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MATN3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ITF2_HUMAN | TCF4 | physical | 25416956 | |
| KR108_HUMAN | KRTAP10-8 | physical | 25416956 | |
| NT2NL_HUMAN | NOTCH2NL | physical | 25416956 | |
| TRFE_HUMAN | TF | physical | 26186194 | |
| PBLD_HUMAN | PBLD | physical | 26186194 | |
| TRFE_HUMAN | TF | physical | 28514442 | |
| PBLD_HUMAN | PBLD | physical | 28514442 | |
| GUAD_HUMAN | GDA | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 607078 | Multiple epiphyseal dysplasia 5 (EDM5) | |||||
| 608728 | Spondyloepimetaphyseal dysplasia MATN3-related (SEMD-MATN3) | |||||
| 140600 | Osteoarthritis 2 (OS2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-295, AND MASSSPECTROMETRY. | |
