M2K6_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M2K6_ARATH
• UniProt AC: Q9FJV0
• Protein Name: Mitogen-activated protein kinase kinase 6
• Gene Name: MKK6
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 356
• Subcellular Localization: Cytoplasm, cytoskeleton, phragmoplast . Localized at the equatorial plane of the phragmoplast.
• Protein Description: The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis. MKK6-MPK13 module positively regulates lateral root formation. Phosphorylates and activates MPK4. Activates MPK5 and MPK13 in vitro..
• Protein Sequence: MVKIKSNLKQLKLSVPAQESPISSFLTASGTFHDGDFLLNQKGLRLTSDEKQSRQSDSKELDFEITAEDLETVKVIGKGSGGVVQLVRHKWVGKFFAMKVIQMNIQEEIRKQIVQELKINQASSQCPHVVVCYHSFYHNGAFSLVLEYMDRGSLADVIRQVKTILEPYLAVVCKQVLLGLVYLHNERHVIHRDIKPSNLLVNHKGEVKISDFGVSASLASSMGQRDTFVGTYNYMSPERISGSTYDYSSDIWSLGMSVLECAIGRFPYLESEDQQNPPSFYELLAAIVENPPPTAPSDQFSPEFCSFVSACIQKDPPARASSLDLLSHPFIKKFEDKDIDLGILVGTLEPPVNYLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	LTSDEKQSRQSDSKE ECCCHHHHCCCCCCC	43.27	23660473
56	Phosphorylation	DEKQSRQSDSKELDF CHHHHCCCCCCCCCE	42.62	23660473
58	Phosphorylation	KQSRQSDSKELDFEI HHHCCCCCCCCCEEE	33.02	23660473
221	Phosphorylation	VSASLASSMGQRDTF CCHHHHHHCCCCCCE	22.71	-
231	Phosphorylation	QRDTFVGTYNYMSPE CCCCEEEEECCCCHH	11.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of M2K6_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
221	S	Phosphorylation	Phosphorylation at Ser-221 and Thr-227 by MAP kinase kinase kinases positively regulates kinase activity.	-
227	T	Phosphorylation	Phosphorylation at Ser-221 and Thr-227 by MAP kinase kinase kinases positively regulates kinase activity.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M2K6_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MPK12_ARATH	MPK12	physical	20802223
MPK4_ARATH	MPK4	physical	20802223
MPK4_ARATH	MPK4	physical	21575092
MPK11_ARATH	MPK11	physical	21575092
MPK6_ARATH	MPK6	physical	21575092
MPK13_ARATH	ATMPK13	physical	21575092
M3K3_ARATH	NP3	physical	21575092

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.