MPK12_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPK12_ARATH
• UniProt AC: Q8GYQ5
• Protein Name: Mitogen-activated protein kinase 12
• Gene Name: MPK12
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 372
• Subcellular Localization: Nucleus .
• Protein Description: Negative regulator of the auxin transduction signaling pathway..
• Protein Sequence: MSGESSSGSTEHCIKVVPTHGGRYVQYNVYGQLFEVSRKYVPPIRPIGRGACGIVCAAVNSVTGEKVAIKKIGNAFDNIIDAKRTLREIKLLRHMDHENVITIKDIVRPPQRDIFNDVYIVYELMDTDLQRILRSNQTLTSDQCRFLVYQLLRGLKYVHSANILHRDLRPSNVLLNSKNELKIGDFGLARTTSDTDFMTEYVVTRWYRAPELLLNCSEYTAAIDIWSVGCILGEIMTGQPLFPGKDYVHQLRLITELVGSPDNSSLGFLRSDNARRYVRQLPRYPKQQFAARFPKMPTTAIDLLERMLVFDPNRRISVDEALGHAYLSPHHDVAKEPVCSTPFSFDFEHPSCTEEHIKELIYKESVKFNPDH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
199	Phosphorylation	TSDTDFMTEYVVTRW CCCCCHHHHHHHHHH	24.94	-
201	Phosphorylation	DTDFMTEYVVTRWYR CCCHHHHHHHHHHCC	7.34	-
204	Phosphorylation	FMTEYVVTRWYRAPE HHHHHHHHHHCCCHH	12.87	24243849

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPK12_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
199	T	Phosphorylation	Dually phosphorylated on Thr-199 and Tyr-201, which activates the enzyme (By similarity).	27923039

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPK12_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of MPK12_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.