MPK13_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MPK13_ARATH
• UniProt AC: Q9LQQ9
• Protein Name: Mitogen-activated protein kinase 13
• Gene Name: MPK13
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 363
• Protein Description: MKK6-MPK13 module positively regulates lateral root formation..
• Protein Sequence: MEKREDGGILTYDGRYVMYNVLGNIFELSSKYIPPIEPIGRGAYGIVCCATNSETNEEVAIKKIANAFDNRVDAKRTLREIKLLSHMDHDNVIKIKDIIELPEKERFEDVYIVYELMDTDLHQIIRSTQTLTDDHCQYFLYQILRGLKYIHSANVLHRDLKPSNLVLNTNCDLKICDFGLARTSNETEIMTEYVVTRWYRAPELLLNSSEYTGAIDIWSVGCIFMEILRRETLFPGKDYVQQLKLITELLGSPDDSDLDFLRSDNARKYVKQLPHVQKQSFREKFPNISPMALDLAEKMLVFDPSKRITVDEALKQPYLASLHEINEEPTCPTPFSFDFEETALDEQDIKELVWRESLHFKNM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
191	Phosphorylation	SNETEIMTEYVVTRW CCCHHHHHHHHHHHC	29.80	-
193	Phosphorylation	ETEIMTEYVVTRWYR CHHHHHHHHHHHCCC	7.34	22074104
196	Phosphorylation	IMTEYVVTRWYRAPE HHHHHHHHHCCCCHH	12.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MPK13_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
191	T	Phosphorylation	Dually phosphorylated on Thr-191 and Tyr-193, which activates the enzyme.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MPK13_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M2K6_ARATH	MKK6	physical	20802223

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.