M3K3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M3K3_ARATH
• UniProt AC: O22042
• Protein Name: Mitogen-activated protein kinase kinase kinase 3
• Gene Name: ANP3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 651
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule-associated proteins such as MAP65-1..
• Protein Sequence: MQDILGSVRRSLVFRSSLAGDDGTSGGGLSGFVGKINSSIRSSRIGLFSKPPPGLPAPRKEEAPSIRWRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKDFLMKCLHKEPSLRLSATELLQHPFVTGKRQEPYPAYRNSLTECGNPITTQGMNVRSSINSLIRRSTCSGLKDVCELGSLRSSIIYPQKSNNSGFGWRDGDSDDLCQTDMDDLCNIESVRNNVLSQSTDLNKSFNPMCDSTDNWSCKFDESPKVMKSKSNLLSYQASQLQTGVPCDEETSLTFAGGSSVAEDDYKGTELKIKSFLDEKAQDLKRLQTPLLEEFHNAMNPGIPQGALGDTNIYNLPNLPSISKTPKRLPSRRLSAISDAMPSPLKSSKRTLNTSRVMQSGTEPTQVNESTKKGVNNSRCFSEIRRKWEEELYEELERHRENLRHAGAGGKTPLSGHKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	ILGSVRRSLVFRSSL HHHHHHHHHHHHHHH	20.51	23111157
17	Phosphorylation	RSLVFRSSLAGDDGT HHHHHHHHHCCCCCC	20.27	23111157
24	Phosphorylation	SLAGDDGTSGGGLSG HHCCCCCCCCCCCHH	31.06	19880383
108	Ubiquitination	IAPSSASKEKTQGHI ECCCCCCCCHHHHHH	64.05	17272265
110	Ubiquitination	PSSASKEKTQGHIRE CCCCCCCHHHHHHHH	50.30	17272265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of M3K3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M3K3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M3K3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CXE12_ARATH	CXE12	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Ubiquitylation

"Multidimensional protein identification technology (MudPIT) analysisof ubiquitinated proteins in plants.";
Maor R., Jones A., Nuehse T.S., Studholme D.J., Peck S.C., Shirasu K.;
Mol. Cell. Proteomics 6:601-610(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-108 AND LYS-110, AND MASSSPECTROMETRY.
PubMed: 17272265