KSG1_SCHPO - dbPTM
KSG1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KSG1_SCHPO
UniProt AC Q12701
Protein Name Serine/threonine-protein kinase ksg1 {ECO:0000305|PubMed:10071224}
Gene Name ksg1 {ECO:0000303|PubMed:10071224}
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 592
Subcellular Localization Cytoplasm .
Protein Description Involved in the control of sexual development and cell growth under stressed conditions. Phosphorylates AGC kinase gad8 at 'Thr-387', activating gad8 kinase activity and promoting sexual development. [PubMed: 12805221 Phosphorylates AGC kinase psk1 at 'Ser-248', activating psk1 kinase activity and promoting phosphorylation of ribosomal protein S6]
Protein Sequence MRNTHNPNETEASEDAENDTQSESDLSFDHGSSEKLNRASLPKTQNSAIPQSNALNTTPNESTSQIDSSPKIPSAVPHISTPNPSSGASTPNIKRVSDFKFGEILGEGSYSTVLTATENSTKREYAIKVLDKRHIIKEKKEKYVNIEKEALCILSKHPGFIKLFYTFQDAHNLYFVLSLARNGELLDYINKLGRFNEICAQYYAALIVDSIDYMHGRGVIHRDLKPENILLDDNMRTKITDFGSAKILNSSHGSHEEDTHHADKPQAHSRSFVGTARYVSPEVLSDKIAGTASDIWAFGCILFQMLAGKPPFVAGNEYLTFQSILHLSYEIPPDISDVASDLIKKLLVLDPKDRLTVDEIHQHPFFNGIKFDNTLWELPPPRLKPFGHTSVLSLSVPNASNKHENGDLTSPLGVPSMVSASTNAAPSPVGTFNRGTLLPCQSNLEEENKEWSSILQDDEKISKIGTLNVYSMSGINGNDAFRFFSSLFRKRKPRTFILTNFGRYLCVASDGEGRKTVKEEIPIKSVGMRCRMVKNNEHGWVVETPTKSWSFEDPNGPASAWVELLDKASSISLPFGNHSVTSFSRSIARSAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
64PhosphorylationTTPNESTSQIDSSPK
CCCCCCCCCCCCCCC		34.1228889911
68PhosphorylationESTSQIDSSPKIPSA
CCCCCCCCCCCCCCC		50.6027738172
69PhosphorylationSTSQIDSSPKIPSAV
CCCCCCCCCCCCCCC		26.8528889911
85PhosphorylationHISTPNPSSGASTPN
CCCCCCCCCCCCCCC		48.3121712547
86PhosphorylationISTPNPSSGASTPNI
CCCCCCCCCCCCCCE		39.3721712547
89PhosphorylationPNPSSGASTPNIKRV
CCCCCCCCCCCEEEC		48.1724763107
90PhosphorylationNPSSGASTPNIKRVS
CCCCCCCCCCEEECC		21.5924763107
271PhosphorylationKPQAHSRSFVGTARY
CCCCCCCCCCCEEEC		27.5729996109
389PhosphorylationRLKPFGHTSVLSLSV
CCCCCCCEEEEEEEC		22.4024763107
390PhosphorylationLKPFGHTSVLSLSVP
CCCCCCEEEEEEECC		18.5221712547
393PhosphorylationFGHTSVLSLSVPNAS
CCCEEEEEEECCCCC		19.2229996109
395PhosphorylationHTSVLSLSVPNASNK
CEEEEEEECCCCCCC		31.9521712547
427PhosphorylationASTNAAPSPVGTFNR
CCCCCCCCCCCCCCC		27.7327738172
442PhosphorylationGTLLPCQSNLEEENK
CCEEECCCCCHHHHH		50.5329996109
485PhosphorylationNDAFRFFSSLFRKRK
CHHHHHHHHHHHCCC		24.3425720772
570PhosphorylationELLDKASSISLPFGN
HHHHHHHCEECCCCC		22.5129996109
572PhosphorylationLDKASSISLPFGNHS
HHHHHCEECCCCCCC		31.7529996109
579PhosphorylationSLPFGNHSVTSFSRS
ECCCCCCCHHHHHHH		30.9624763107
581PhosphorylationPFGNHSVTSFSRSIA
CCCCCCHHHHHHHHH		27.3724763107
582PhosphorylationFGNHSVTSFSRSIAR
CCCCCHHHHHHHHHH		21.0421712547
584PhosphorylationNHSVTSFSRSIARSA
CCCHHHHHHHHHHHC		25.5321712547
586PhosphorylationSVTSFSRSIARSAV-
CHHHHHHHHHHHCC-		21.2821712547
590PhosphorylationFSRSIARSAV-----
HHHHHHHHCC-----		25.1021712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KSG1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KSG1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KSG1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GAD8_SCHPOgad8genetic
12805221
PCK2_SCHPOpck2genetic
14625898
PCK1_SCHPOpck1physical
14625898
GAD8_SCHPOgad8physical
12805221
PCK1_SCHPOpck1genetic
14625898
PSK1_SCHPOpsk1physical
22976295
YH5B_SCHPOSPBC215.11cgenetic
22681890
XLF1_SCHPOxlf1genetic
22681890
DCTD_SCHPOdcd1genetic
22681890
LEM2_SCHPOlem2genetic
22681890
YEEB_SCHPOSPAC19A8.11cgenetic
22681890
BYR3_SCHPObyr3genetic
22681890
RM01_SCHPOSPAC1610.02cgenetic
22681890
YK42_SCHPOtos4genetic
22681890
PCK1_SCHPOpck1physical
25416816
PCK2_SCHPOpck2physical
25416816
TOR1_SCHPOtor1genetic
25416816
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KSG1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64 AND SER-69, AND MASSSPECTROMETRY.

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