KLK15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLK15_HUMAN
• UniProt AC: Q9H2R5
• Protein Name: Kallikrein-15
• Gene Name: KLK15
• Organism: Homo sapiens (Human).
• Sequence Length: 256
• Subcellular Localization: Secreted .
• Protein Description: Protease whose physiological substrate is not yet known..
• Protein Sequence: MWLLLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHCQSRFMRVRLGEHNLRKRDGPEQLRTTSRVIPHPRYEARSHRNDIMLLRLVQPARLNPQVRPAVLPTRCPHPGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISDTSCDKSYPGRLTNTMVCAGAEGRGAESCEGDSGGPLVCGGILQGIVSWGDVPCDNTTKPGVYTKVCHYLEWIRETMKRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
90	Phosphorylation	PEQLRTTSRVIPHPR HHHHHCCCCCCCCHH	24.76	27251275
98	Phosphorylation	RVIPHPRYEARSHRN CCCCCHHHHHHHCCC	20.56	27251275
102	Phosphorylation	HPRYEARSHRNDIML CHHHHHHHCCCCEEE	33.57	27251275
156	Phosphorylation	NEPGTAGSPRSQVSL CCCCCCCCCCCCCCC	18.06	26853621
171	N-linked_Glycosylation	PDTLHCANISIISDT CCCEEECEEEEEECC	33.65	UniProtKB CARBOHYD
232	N-linked_Glycosylation	WGDVPCDNTTKPGVY CCCCCCCCCCCCCHH	57.26	UniProtKB CARBOHYD
235	Ubiquitination	VPCDNTTKPGVYTKV CCCCCCCCCCHHHHH	37.42	-
241	Ubiquitination	TKPGVYTKVCHYLEW CCCCHHHHHHHHHHH	25.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLK15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLK15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLK15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR103_HUMAN	KRTAP10-3	physical	25416956
SC16A_HUMAN	SEC16A	physical	26186194
CBWD1_HUMAN	CBWD1	physical	26186194
HXD13_HUMAN	HOXD13	physical	26186194
ABHD3_HUMAN	ABHD3	physical	26186194
SMG7_HUMAN	SMG7	physical	26186194
MCAT_HUMAN	SLC25A20	physical	26186194
SMG7_HUMAN	SMG7	physical	28514442
MCAT_HUMAN	SLC25A20	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.