| UniProt ID | KIRR2_HUMAN | |
|---|---|---|
| UniProt AC | Q6UWL6 | |
| Protein Name | Kin of IRRE-like protein 2 | |
| Gene Name | KIRREL2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 708 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin. |
|
| Protein Description | May regulate basal insulin secretion.. | |
| Protein Sequence | MLRMRVPALLVLLFCFRGRAGPSPHFLQQPEDLVVLLGEEARLPCALGAYWGLVQWTKSGLALGGQRDLPGWSRYWISGNAANGQHDLHIRPVELEDEASYECQATQAGLRSRPAQLHVLVPPEAPQVLGGPSVSLVAGVPANLTCRSRGDARPTPELLWFRDGVLLDGATFHQTLLKEGTPGSVESTLTLTPFSHDDGATFVCRARSQALPTGRDTAITLSLQYPPEVTLSASPHTVQEGEKVIFLCQATAQPPVTGYRWAKGGSPVLGARGPRLEVVADASFLTEPVSCEVSNAVGSANRSTALDVLFGPILQAKPEPVSVDVGEDASFSCAWRGNPLPRVTWTRRGGAQVLGSGATLRLPSVGPEDAGDYVCRAEAGLSGLRGGAAEARLTVNAPPVVTALHSAPAFLRGPARLQCLVFASPAPDAVVWSWDEGFLEAGSQGRFLVETFPAPESRGGLGPGLISVLHISGTQESDFSRSFNCSARNRLGEGGAQASLGRRDLLPTVRIVAGVAAATTTLLMVITGVALCCWRHSKASASFSEQKNLMRIPGSSDGSSSRGPEEEETGSREDRGPIVHTDHSDLVLEEKGTLETKDPTNGYYKVRGVSVSLSLGEAPGGGLFLPPPSPLGPPGTPTFYDFNPHLGMVPPCRLYRARAGYLTTPHPRAFTSYIKPTSFGPPDLAPGTPPFPYAAFPTPSHPRLQTHV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 (in isoform 5) | Phosphorylation | - | 30.04 | 22210691 | |
| 45 (in isoform 5) | Phosphorylation | - | 6.05 | 22210691 | |
| 143 | N-linked_Glycosylation | LVAGVPANLTCRSRG EEECCCCCCEECCCC | 29.79 | UniProtKB CARBOHYD | |
| 188 | O-linked_Glycosylation | TPGSVESTLTLTPFS CCCCEEEEEEECCCC | 15.40 | OGP | |
| 190 | O-linked_Glycosylation | GSVESTLTLTPFSHD CCEEEEEEECCCCCC | 28.77 | OGP | |
| 208 | Phosphorylation | TFVCRARSQALPTGR EEEEEECCCCCCCCC | 20.86 | 27251275 | |
| 213 | Phosphorylation | ARSQALPTGRDTAIT ECCCCCCCCCCEEEE | 45.78 | 22985185 | |
| 220 | O-linked_Glycosylation | TGRDTAITLSLQYPP CCCCEEEEEEEECCC | 14.08 | OGP | |
| 225 | Phosphorylation | AITLSLQYPPEVTLS EEEEEEECCCEEEEE | 26.50 | - | |
| 263 | Ubiquitination | VTGYRWAKGGSPVLG CCCCCCCCCCCCCCC | 57.77 | - | |
| 301 | N-linked_Glycosylation | SNAVGSANRSTALDV CCCCCCCCHHHHHHH | 39.88 | UniProtKB CARBOHYD | |
| 382 | Phosphorylation | CRAEAGLSGLRGGAA HHHHHCCCCCCCCCE | 34.56 | 24719451 | |
| 484 | N-linked_Glycosylation | SDFSRSFNCSARNRL CCCCCCEECHHHCCC | 21.78 | UniProtKB CARBOHYD | |
| 508 | Phosphorylation | GRRDLLPTVRIVAGV CCCCHHCHHHHHHHH | 23.53 | - | |
| 519 | Phosphorylation | VAGVAAATTTLLMVI HHHHHHHHHHHHHHH | 18.65 | 22210691 | |
| 520 | Phosphorylation | AGVAAATTTLLMVIT HHHHHHHHHHHHHHH | 15.66 | 22210691 | |
| 521 | Phosphorylation | GVAAATTTLLMVITG HHHHHHHHHHHHHHH | 17.34 | 22210691 | |
| 547 | Ubiquitination | SASFSEQKNLMRIPG CCCHHHCCCCCCCCC | 48.25 | - | |
| 555 | Phosphorylation | NLMRIPGSSDGSSSR CCCCCCCCCCCCCCC | 21.65 | 17081983 | |
| 556 | Phosphorylation | LMRIPGSSDGSSSRG CCCCCCCCCCCCCCC | 52.48 | 25262027 | |
| 559 | Phosphorylation | IPGSSDGSSSRGPEE CCCCCCCCCCCCCCC | 30.08 | 17081983 | |
| 560 | Phosphorylation | PGSSDGSSSRGPEEE CCCCCCCCCCCCCCC | 29.59 | 25262027 | |
| 561 | Phosphorylation | GSSDGSSSRGPEEEE CCCCCCCCCCCCCCC | 42.84 | 25262027 | |
| 571 | Phosphorylation | PEEEETGSREDRGPI CCCCCCCCCCCCCCE | 39.66 | - | |
| 603 | Phosphorylation | TKDPTNGYYKVRGVS EECCCCCEEEEEEEE | 11.37 | 25884760 | |
| 604 | Phosphorylation | KDPTNGYYKVRGVSV ECCCCCEEEEEEEEE | 12.38 | - | |
| 661 | Phosphorylation | LYRARAGYLTTPHPR EEECCCCCCCCCCCC | 10.41 | 27642862 | |
| 671 | Phosphorylation | TPHPRAFTSYIKPTS CCCCCCCCCCCCCCC | 21.45 | 27642862 | |
| 673 | Phosphorylation | HPRAFTSYIKPTSFG CCCCCCCCCCCCCCC | 15.20 | 25884760 | |
| 675 | Ubiquitination | RAFTSYIKPTSFGPP CCCCCCCCCCCCCCC | 33.73 | - | |
| 678 | Phosphorylation | TSYIKPTSFGPPDLA CCCCCCCCCCCCCCC | 36.41 | - | |
| 688 | Phosphorylation | PPDLAPGTPPFPYAA CCCCCCCCCCCCCCC | 27.08 | 22817900 | |
| 693 | Phosphorylation | PGTPPFPYAAFPTPS CCCCCCCCCCCCCCC | 15.79 | 27642862 | |
| 700 | Phosphorylation | YAAFPTPSHPRLQTH CCCCCCCCCCCCCCC | 48.91 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KIRR2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KIRR2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KIRR2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CPSM_HUMAN | CPS1 | physical | 26186194 | |
| MK03_HUMAN | MAPK3 | physical | 26186194 | |
| FBX11_HUMAN | FBXO11 | physical | 26186194 | |
| PIGS_HUMAN | PIGS | physical | 26186194 | |
| P3H3_HUMAN | LEPREL2 | physical | 26186194 | |
| AURKA_HUMAN | AURKA | physical | 26186194 | |
| MANBA_HUMAN | MANBA | physical | 26186194 | |
| VHL_HUMAN | VHL | physical | 26186194 | |
| VHL_HUMAN | VHL | physical | 28514442 | |
| FBX11_HUMAN | FBXO11 | physical | 28514442 | |
| CPSM_HUMAN | CPS1 | physical | 28514442 | |
| AURKA_HUMAN | AURKA | physical | 28514442 | |
| MANBA_HUMAN | MANBA | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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