IP6K3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IP6K3_HUMAN
• UniProt AC: Q96PC2
• Protein Name: Inositol hexakisphosphate kinase 3
• Gene Name: IP6K3
• Organism: Homo sapiens (Human).
• Sequence Length: 410
• Subcellular Localization: Cytoplasm .
• Protein Description: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4..
• Protein Sequence: MVVQNSADAGDMRAGVQLEPFLHQVGGHMSVMKYDEHTVCKPLVSREQRFYESLPLAMKRFTPQYKGTVTVHLWKDSTGHLSLVANPVKESQEPFKVSTESAAVAIWQTLQQTTGSNGSDCTLAQWPHAQLARSPKESPAKALLRSEPHLNTPAFSLVEDTNGNQVERKSFNPWGLQCHQAHLTRLCSEYPENKRHRFLLLENVVSQYTHPCVLDLKMGTRQHGDDASEEKKARHMRKCAQSTSACLGVRICGMQVYQTDKKYFLCKDKYYGRKLSVEGFRQALYQFLHNGSHLRRELLEPILHQLRALLSVIRSQSSYRFYSSSLLVIYDGQEPPERAPGSPHPHEAPQAAHGSSPGGLTKVDIRMIDFAHTTYKGYWNEHTTYDGPDPGYIFGLENLIRILQDIQEGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	GHMSVMKYDEHTVCK CCCEEECCCCCCCCH	14.41	-
45	Phosphorylation	TVCKPLVSREQRFYE CCCHHCCCHHHHHHH	37.47	-
141	Ubiquitination	SPKESPAKALLRSEP CCCCCHHHHHHHCCC	42.84	-
206	Phosphorylation	LLLENVVSQYTHPCV EEHHCHHHHCCCCCE	17.12	22210691
208	Phosphorylation	LENVVSQYTHPCVLD HHCHHHHCCCCCEEE	10.26	22210691
209	Phosphorylation	ENVVSQYTHPCVLDL HCHHHHCCCCCEEEE	16.23	22210691
242	Phosphorylation	HMRKCAQSTSACLGV HHHHHHHHHHHHHCH	13.05	22817900
243	Phosphorylation	MRKCAQSTSACLGVR HHHHHHHHHHHHCHH	14.30	22817900
244	Phosphorylation	RKCAQSTSACLGVRI HHHHHHHHHHHCHHH	23.41	22817900
276	Phosphorylation	KYYGRKLSVEGFRQA CCCCEECCHHHHHHH	22.58	27499020
315	Phosphorylation	ALLSVIRSQSSYRFY HHHHHHHCCCCEEEE	24.24	28122231
317	Phosphorylation	LSVIRSQSSYRFYSS HHHHHCCCCEEEECE	30.50	28122231
318	Phosphorylation	SVIRSQSSYRFYSSS HHHHCCCCEEEECEE	16.82	28122231
319	Phosphorylation	VIRSQSSYRFYSSSL HHHCCCCEEEECEEE	15.25	28122231
373	Phosphorylation	RMIDFAHTTYKGYWN EEEECCCCCCCCCCC	28.52	24043423
374	Phosphorylation	MIDFAHTTYKGYWNE EEECCCCCCCCCCCC	17.23	24043423
375	Phosphorylation	IDFAHTTYKGYWNEH EECCCCCCCCCCCCC	11.99	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IP6K3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IP6K3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IP6K3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M3K3_HUMAN	MAP3K3	physical	26496610
PCCA_HUMAN	PCCA	physical	26496610
BAG6_HUMAN	BAG6	physical	26496610
UBL4A_HUMAN	UBL4A	physical	26496610
TADBP_HUMAN	TARDBP	physical	26496610
PF21A_HUMAN	PHF21A	physical	26496610
SRRT_HUMAN	SRRT	physical	26496610
ELP3_HUMAN	ELP3	physical	26496610
BI2L1_HUMAN	BAIAP2L1	physical	26496610
NU107_HUMAN	NUP107	physical	26496610
PCY1A_HUMAN	PCYT1A	physical	28514442
NECA1_HUMAN	NECAB1	physical	28514442
PROZ_HUMAN	PROZ	physical	28514442
ACP7_HUMAN	PAPL	physical	28514442
T3HPD_HUMAN	L3HYPDH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242; THR-243 ANDSER-244, AND MASS SPECTROMETRY.
PubMed: 18187866