NECA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NECA1_HUMAN
• UniProt AC: Q8N987
• Protein Name: N-terminal EF-hand calcium-binding protein 1
• Gene Name: NECAB1
• Organism: Homo sapiens (Human).
• Sequence Length: 351
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MEDSQETSPSSNNSSEELSSALHLSKGMSIFLDILRRADKNDDGKLSFEEFKAYFADGVLSGEELHELFHTIDTHNTNNLDTEELCEYFSQHLGEYENVLAALEDLNLSILKAMGKTKKDYQEASNLEQFVTRFLLKETLNQLQSLQNSLECAMETTEEQTRQERQGPAKPEVLSIQWPGKRSSRRVQRHNSFSPNSPQFNVSGPGLLEEDNQWMTQINRLQKLIDRLEKKDLKLEPPEEEIIEGNTKSHIMLVQRQMSVIEEDLEEFQLALKHYVESASSQSGCLRISIQKLSNESRYMIYEFWENSSVWNSHLQTNYSKTFQRSNVDFLETPELTSTMLVPASWWILNN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MEDSQETSPSS ----CCCCCCCCCCC	19.33	-
109	Phosphorylation	ALEDLNLSILKAMGK HHHHHCHHHHHHCCC	25.46	24719451
192	Phosphorylation	RRVQRHNSFSPNSPQ CCHHHCCCCCCCCCC	22.45	28857561
194	Phosphorylation	VQRHNSFSPNSPQFN HHHCCCCCCCCCCCC	24.00	28857561
197	Phosphorylation	HNSFSPNSPQFNVSG CCCCCCCCCCCCCCC	24.38	28857561
234	Ubiquitination	RLEKKDLKLEPPEEE HHHHCCCCCCCCHHH	62.02	30230243
259	Phosphorylation	MLVQRQMSVIEEDLE HHHHHHHHHHHHHHH	16.17	28348404
289	Phosphorylation	QSGCLRISIQKLSNE CCCEEEEEEEECCCC	16.72	22210691
299	Phosphorylation	KLSNESRYMIYEFWE ECCCCCCEEEEEHHH	9.35	-
302	Phosphorylation	NESRYMIYEFWENSS CCCCEEEEEHHHCCH	6.64	-
308	Phosphorylation	IYEFWENSSVWNSHL EEEHHHCCHHHHHHH	18.11	25311616
320	Phosphorylation	SHLQTNYSKTFQRSN HHHHHCCCHHCCCCC	27.56	25311616

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NECA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NECA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NECA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NECA3_HUMAN	NECAB3	physical	28514442
NECA2_HUMAN	NECAB2	physical	28514442
UTP4_HUMAN	CIRH1A	physical	28514442
KANL2_HUMAN	KANSL2	physical	28514442
MPRIP_HUMAN	MPRIP	physical	28514442
RN138_HUMAN	RNF138	physical	28514442
MCRS1_HUMAN	MCRS1	physical	28514442
CCDC6_HUMAN	CCDC6	physical	28514442
RAI14_HUMAN	RAI14	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.