GIPC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GIPC2_HUMAN
• UniProt AC: Q8TF65
• Protein Name: PDZ domain-containing protein GIPC2
• Gene Name: GIPC2
• Organism: Homo sapiens (Human).
• Sequence Length: 315
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MPLKLRGKKKAKSKETAGLVEGEPTGAGGGSLSASRAPARRLVFHAQLAHGSATGRVEGFSSIQELYAQIAGAFEISPSEILYCTLNTPKIDMERLLGGQLGLEDFIFAHVKGIEKEVNVYKSEDSLGLTITDNGVGYAFIKRIKDGGVIDSVKTICVGDHIESINGENIVGWRHYDVAKKLKELKKEELFTMKLIEPKKAFEIELRSKAGKSSGEKIGCGRATLRLRSKGPATVEEMPSETKAKAIEKIDDVLELYMGIRDIDLATTMFEAGKDKVNPDEFAVALDETLGDFAFPDEFVFDVWGVIGDAKRRGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	RGKKKAKSKETAGLV CCCCCCCCCCCCCCC	40.35	23312004
16	Phosphorylation	KKAKSKETAGLVEGE CCCCCCCCCCCCCCC	29.75	23312004
31	Phosphorylation	PTGAGGGSLSASRAP CCCCCCCCCCCCCCC	23.56	28857561
33	Phosphorylation	GAGGGSLSASRAPAR CCCCCCCCCCCCCHH	26.37	28857561
35	Phosphorylation	GGGSLSASRAPARRL CCCCCCCCCCCHHHH	26.12	28857561
54	Phosphorylation	QLAHGSATGRVEGFS EHHCCCCCCCCCCCC	27.50	28857561
192	Phosphorylation	LKKEELFTMKLIEPK HHHHHCEEEEECCCC	26.48	28857561
229	Phosphorylation	RATLRLRSKGPATVE CEEEEEHHCCCCCHH	46.70	28857561
234	Phosphorylation	LRSKGPATVEEMPSE EHHCCCCCHHCCCCC	31.42	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GIPC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GIPC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GIPC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGS21_HUMAN	IGSF21	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
PTN_HUMAN	PTN	physical	16169070
GIPC2_HUMAN	GIPC2	physical	25416956
ZBT26_HUMAN	ZBTB26	physical	25416956
SH3B4_HUMAN	SH3BP4	physical	26186194
CO1A1_HUMAN	COL1A1	physical	26186194
DP13A_HUMAN	APPL1	physical	26186194
SH3B4_HUMAN	SH3BP4	physical	28514442
DP13A_HUMAN	APPL1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.