FRMD3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRMD3_HUMAN
• UniProt AC: A2A2Y4
• Protein Name: FERM domain-containing protein 3
• Gene Name: FRMD3
• Organism: Homo sapiens (Human).
• Sequence Length: 597
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Description: Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer..
• Protein Sequence: MFASCHCVPRGRRTMKMIHFRSSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPEKQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQSPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDVCKLKFEGKTFYVIGTQKEKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPLQPLLPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEEDKIKEEPLTISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDTDSFEDLEADENAFLIAEEEELKEARRALSWSYDILTGHIRVNPLVKSFSRLLVVGLGLLLFVFPLLLLLLESGIDLSFLCEIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYMLGCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	CVPRGRRTMKMIHFR EECCCCCEEEEEEEC	21.56	-
22	Phosphorylation	MKMIHFRSSSVKSLS EEEEEECCHHHHHHC	26.48	28857561
23	Phosphorylation	KMIHFRSSSVKSLSQ EEEEECCHHHHHHCH	34.59	24114839
24	Phosphorylation	MIHFRSSSVKSLSQE EEEECCHHHHHHCHH	34.51	27422710
26	Ubiquitination	HFRSSSVKSLSQEMR EECCHHHHHHCHHHC	47.85	33845483
27	Phosphorylation	FRSSSVKSLSQEMRC ECCHHHHHHCHHHCC	30.97	27422710
29	Phosphorylation	SSSVKSLSQEMRCTI CHHHHHHCHHHCCEE	31.05	21955146
66	Phosphorylation	DHICNYYSLLEKDYF HHHHHHHHHHHCCCC	19.00	24719451
75	Ubiquitination	LEKDYFGIRYVDPEK HHCCCCCEEECCHHH	1.74	33845483
76	Ubiquitination	EKDYFGIRYVDPEKQ HCCCCCEEECCHHHH	26.29	29967540
92	Phosphorylation	HWLEPNKSIFKQMKT CCCCCCHHHHHHHCC	39.64	24719451
99	Phosphorylation	SIFKQMKTHPPYTMC HHHHHHCCCCCEEEE	33.98	26657352
104	Phosphorylation	MKTHPPYTMCFRVKF HCCCCCEEEEEEEEE	17.15	26657352
112	Phosphorylation	MCFRVKFYPHEPLKI EEEEEEECCCCCCCC	9.65	22210691
145	Ubiquitination	HGRLLCSFSDAAYLG CCEEEEECCCHHHHH	8.16	33845483
216	Phosphorylation	NLLLKAHTLETYGVD HHHHEECCCEECCCC	31.02	26270265
219	Phosphorylation	LKAHTLETYGVDPHP HEECCCEECCCCCCC	28.78	22617229
225	Ubiquitination	ETYGVDPHPCKDSTG EECCCCCCCCCCCCC	35.61	33845483
233	Phosphorylation	PCKDSTGTTTFLGFT CCCCCCCCCEEEEEE	23.81	26552605
234	Phosphorylation	CKDSTGTTTFLGFTA CCCCCCCCEEEEEEE	19.52	26552605
235	Phosphorylation	KDSTGTTTFLGFTAA CCCCCCCEEEEEEEE	19.39	26552605
240	Phosphorylation	TTTFLGFTAAGFVVF CCEEEEEEEEEEEEE	17.50	26552605
269	Ubiquitination	CKLKFEGKTFYVIGT EEEEECCEEEEEEEE	28.41	33845483
276	Phosphorylation	KTFYVIGTQKEKKAM EEEEEEEEHHHHHEE	25.91	-
281	Ubiquitination	IGTQKEKKAMLAFHT EEEHHHHHEEEEEEC	39.87	-
288	Phosphorylation	KAMLAFHTSTPAACK HEEEEEECCCHHHHH	28.04	29083192
289	Phosphorylation	AMLAFHTSTPAACKH EEEEEECCCHHHHHH	24.67	29083192
290	Phosphorylation	MLAFHTSTPAACKHL EEEEECCCHHHHHHH	20.36	29083192
295	Ubiquitination	TSTPAACKHLWKCGV CCCHHHHHHHHHCCC	36.69	33845483
310	Phosphorylation	ENQAFYKYAKSSQIK CCHHHHHHHHHCCCE	14.10	28796482
313	Phosphorylation	AFYKYAKSSQIKTVS HHHHHHHHCCCEEEE	21.21	28796482
314	Phosphorylation	FYKYAKSSQIKTVSS HHHHHHHCCCEEEEC	34.91	28796482
318	Phosphorylation	AKSSQIKTVSSSKIF HHHCCCEEEECCCEE	27.52	29978859
320	Phosphorylation	SSQIKTVSSSKIFFK HCCCEEEECCCEEEC	33.84	29978859
321	Phosphorylation	SQIKTVSSSKIFFKG CCCEEEECCCEEECC	31.17	29978859
322	Phosphorylation	QIKTVSSSKIFFKGS CCEEEECCCEEECCC	23.43	29978859
327	Methylation	SSSKIFFKGSRFRYS ECCCEEECCCCEEEC	45.27	-
334	Phosphorylation	KGSRFRYSGKVAKEV CCCCEEECCHHHHHH	28.07	29496963
339	Ubiquitination	RYSGKVAKEVVEASS EECCHHHHHHHHHHH	54.77	33845483
345	Phosphorylation	AKEVVEASSKIQREP HHHHHHHHHHHCCCC	20.75	-
363	Phosphorylation	HRANITQSRSSHSLN HHCCCCCCCCCCCCC	26.02	29414761
365	Phosphorylation	ANITQSRSSHSLNKQ CCCCCCCCCCCCCCE	37.34	29507054
366	Phosphorylation	NITQSRSSHSLNKQL CCCCCCCCCCCCCEE	18.91	30177828
368	Phosphorylation	TQSRSSHSLNKQLII CCCCCCCCCCCEEEE	35.27	29414761
375	Ubiquitination	SLNKQLIINMEPLQP CCCCEEEEECCCCCC	5.66	29967540
386	Phosphorylation	PLQPLLPSPSEQEEE CCCCCCCCCCCCCCC	40.82	28348404
388	Phosphorylation	QPLLPSPSEQEEELP CCCCCCCCCCCCCCC	57.14	28348404
409	Phosphorylation	LPKEENISAPLISSS CCCCCCCCCCCCCCC	35.10	27251275
414	Phosphorylation	NISAPLISSSPVKAA CCCCCCCCCCCHHHH	32.23	29255136
415	Phosphorylation	ISAPLISSSPVKAAR CCCCCCCCCCHHHHH	31.50	29255136
416	Phosphorylation	SAPLISSSPVKAARE CCCCCCCCCHHHHHH	27.24	29255136
419	Ubiquitination	LISSSPVKAAREYED CCCCCCHHHHHHCCC	39.45	29967540
429	Phosphorylation	REYEDPPSEEEDKIK HHCCCCCCHHHHHHC	64.13	28355574
456	Phosphorylation	PSASLLPTPVDDDEI CCCCCCCCCCCHHHC	35.59	26853621
480	Phosphorylation	LELEREDTDSFEDLE EEEEECCCCCHHHHH	28.88	27732954
482	Phosphorylation	LEREDTDSFEDLEAD EEECCCCCHHHHHHH	32.40	25884760
502	Ubiquitination	IAEEEELKEARRALS EECHHHHHHHHHHHH	53.24	-
509	Phosphorylation	KEARRALSWSYDILT HHHHHHHHHHHHHHH	17.00	28348404
511	Phosphorylation	ARRALSWSYDILTGH HHHHHHHHHHHHHCC	15.00	28348404
529	Phosphorylation	NPLVKSFSRLLVVGL CHHHHHHHHHHHHHH	29.16	17081983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRMD3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRMD3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRMD3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPD_HUMAN	ATP5D	physical	24366813
ATPO_HUMAN	ATP5O	physical	24366813
OXA1L_HUMAN	OXA1L	physical	24366813
COL12_HUMAN	COLEC12	physical	28514442
LCLT1_HUMAN	LCLAT1	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442
REEP4_HUMAN	REEP4	physical	28514442
F234B_HUMAN	KIAA1467	physical	28514442
LARG2_HUMAN	GYLTL1B	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.