| UniProt ID | FOXI1_HUMAN | |
|---|---|---|
| UniProt AC | Q12951 | |
| Protein Name | Forkhead box protein I1 | |
| Gene Name | FOXI1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 378 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).. | |
| Protein Sequence | MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPVDSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHFYNSVNTSGVLYPREGTEV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSFDLPAP ------CCCCCCCCC | 39.45 | 23663014 | |
| 3 | Phosphorylation | -----MSSFDLPAPS -----CCCCCCCCCC | 22.83 | 23663014 | |
| 10 | Phosphorylation | SFDLPAPSPPRCSPQ CCCCCCCCCCCCCCC | 50.03 | 23663014 | |
| 126 | Phosphorylation | MKLVRPPYSYSALIA HHHHCCCCCHHHHHH | 23.95 | 18669648 | |
| 127 | Phosphorylation | KLVRPPYSYSALIAM HHHCCCCCHHHHHHH | 20.56 | 18669648 | |
| 170 | Phosphorylation | SKAGWQNSIRHNLSL CHHHHHHHHHHCCCH | 13.10 | 27251275 | |
| 176 | Phosphorylation | NSIRHNLSLNDCFKK HHHHHCCCHHHHHHC | 30.37 | 27251275 | |
| 220 | Phosphorylation | RRKRKRKSDVSSSTA CCCCCCHHHCCHHHH | 47.48 | 22617229 | |
| 234 | Phosphorylation | ASLALEKTESSLPVD HHHHHHHCCCCCCCC | 31.55 | 26270265 | |
| 236 | Phosphorylation | LALEKTESSLPVDSP HHHHHCCCCCCCCCC | 42.26 | 26270265 | |
| 237 | Phosphorylation | ALEKTESSLPVDSPK HHHHCCCCCCCCCCC | 30.38 | 26270265 | |
| 242 | Phosphorylation | ESSLPVDSPKTTEPQ CCCCCCCCCCCCCCH | 28.64 | 22617229 | |
| 256 | Phosphorylation | QDILDGASPGGTTSS HHHHCCCCCCCCCCC | 29.61 | 28348404 | |
| 260 | Phosphorylation | DGASPGGTTSSPEKR CCCCCCCCCCCCCCC | 29.44 | 28348404 | |
| 261 | Phosphorylation | GASPGGTTSSPEKRP CCCCCCCCCCCCCCC | 30.40 | 28348404 | |
| 262 | Phosphorylation | ASPGGTTSSPEKRPS CCCCCCCCCCCCCCC | 43.67 | 28348404 | |
| 263 | Phosphorylation | SPGGTTSSPEKRPSP CCCCCCCCCCCCCCC | 34.68 | 28348404 | |
| 269 | Phosphorylation | SSPEKRPSPPPSGAP CCCCCCCCCCCCCCC | 54.81 | 28348404 | |
| 273 | Phosphorylation | KRPSPPPSGAPCLNS CCCCCCCCCCCCHHH | 54.05 | 28348404 | |
| 280 | Phosphorylation | SGAPCLNSFLSSMTA CCCCCHHHHHHHCCE | 18.02 | 28348404 | |
| 290 | Phosphorylation | SSMTAYVSGGSPTSH HHCCEECCCCCCCCC | 25.43 | 28348404 | |
| 293 | Phosphorylation | TAYVSGGSPTSHPLV CEECCCCCCCCCCCC | 28.64 | 28348404 | |
| 295 | Phosphorylation | YVSGGSPTSHPLVTP ECCCCCCCCCCCCCC | 41.17 | 28348404 | |
| 296 | Phosphorylation | VSGGSPTSHPLVTPG CCCCCCCCCCCCCCC | 26.88 | 28348404 | |
| 301 | Phosphorylation | PTSHPLVTPGLSPEP CCCCCCCCCCCCCCC | 21.23 | 28348404 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FOXI1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FOXI1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FOXI1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| NSMA3_HUMAN | SMPD4 | physical | 25609649 | |
| TIF1A_HUMAN | TRIM24 | physical | 25609649 | |
| TRI33_HUMAN | TRIM33 | physical | 25609649 | |
| DX39A_HUMAN | DDX39A | physical | 25609649 | |
| HEAT1_HUMAN | HEATR1 | physical | 25609649 | |
| PDS5A_HUMAN | PDS5A | physical | 25609649 | |
| TOM40_HUMAN | TOMM40 | physical | 25609649 | |
| SYVC_HUMAN | VARS | physical | 25609649 | |
| FAS_HUMAN | FASN | physical | 25609649 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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