| UniProt ID | FCP1_SCHPO | |
|---|---|---|
| UniProt AC | Q9P376 | |
| Protein Name | RNA polymerase II subunit A C-terminal domain phosphatase | |
| Gene Name | fcp1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 723 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II.. | |
| Protein Sequence | MSKRLTPIHLPNSLNYPIEIASCLVPQGSYVKKGTPLLLYRFFTKVKEDQEDGSEVYVDREFVEQFECPVEGELVEWAVKKEESIENFSKIVAKLHEPCTHEVNYGGLCAICGKNITSQDYMGYSDMARANISMTHNTGDLTVSLEEASRLESENVKRLRQEKRLSLIVDLDQTIIHATVDPTVGEWMSDPGNVNYDVLRDVRSFNLQEGPSGYTSCYYIKFRPGLAQFLQKISELYELHIYTMGTKAYAKEVAKIIDPTGKLFQDRVLSRDDSGSLAQKSLRRLFPCDTSMVVVIDDRGDVWDWNPNLIKVVPYEFFVGIGDINSNFLAKSTPLPEQEQLIPLEIPKDEPDSVDEINEENEETPEYDSSNSSYAQDSSTIPEKTLLKDTFLQNREALEEQNKERVTALELQKSERPLAKQQNALLEDEGKPTPSHTLLHNRDHELERLEKVLKDIHAVYYEEENDISSRSGNHKHANVGLIIPKMKQKVLKGCRLLFSGVIPLGVDVLSSDIAKWAMSFGAEVVLDFSVPPTHLIAAKIRTEKVKKAVSMGNIKVVKLNWLTESLSQWKRLPESDYLLYPSYDLPDRNLSEHSYSSSSDDEQRISELNDRELDEIDWQAADQDVENALKDLSDDNDFDTGSISASQSQPEALEVNTPIKRKADLIQPSYNYDGEKRRKENDNHEGYDLLPNSSTKGEESAENENELDDLADIMEAELSKDTA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 633 | Phosphorylation | ENALKDLSDDNDFDT HHHHHHCCCCCCCCC | 53.72 | 29996109 | |
| 640 | Phosphorylation | SDDNDFDTGSISASQ CCCCCCCCCCCCCCC | 32.59 | 24763107 | |
| 642 | Phosphorylation | DNDFDTGSISASQSQ CCCCCCCCCCCCCCC | 18.57 | 21712547 | |
| 657 | Phosphorylation | PEALEVNTPIKRKAD CCHHCCCCCCCCCHH | 31.41 | 24763107 | |
| 693 | Phosphorylation | GYDLLPNSSTKGEES CCCCCCCCCCCCHHH | 37.13 | 21712547 | |
| 694 | Phosphorylation | YDLLPNSSTKGEESA CCCCCCCCCCCHHHC | 40.55 | 21712547 | |
| 695 | Phosphorylation | DLLPNSSTKGEESAE CCCCCCCCCCHHHCC | 42.78 | 21712547 | |
| 700 | Phosphorylation | SSTKGEESAENENEL CCCCCHHHCCCCHHH | 36.26 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FCP1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FCP1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FCP1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RPB3_SCHPO | rpb3 | physical | 11839823 | |
| RPB4_SCHPO | rpb4 | physical | 11839823 | |
| RPB1_SCHPO | rpb1 | physical | 11839823 | |
| RPB2_SCHPO | rpb2 | physical | 11839823 | |
| RPAB1_SCHPO | rpb5 | physical | 11839823 | |
| RPAB2_SCHPO | rpb6 | physical | 11839823 | |
| RPB7_SCHPO | rpb7 | physical | 11839823 | |
| RPAB4_SCHPO | rpc10 | physical | 11839823 | |
| RPAB5_SCHPO | rpb10 | physical | 11839823 | |
| RPAB3_SCHPO | rpb8 | physical | 11839823 | |
| RPB9_SCHPO | rpb9 | physical | 11839823 | |
| RPB11_SCHPO | rpb11 | physical | 11839823 | |
| T2FB_SCHPO | tfg2 | physical | 11839823 | |
| T2FB_SCHPO | tfg2 | physical | 15616156 | |
| RPB1_SCHPO | rpb1 | genetic | 25883047 | |
| SSU72_SCHPO | ssu72 | genetic | 25883047 | |
| SPT5_SCHPO | spt5 | physical | 25883047 | |
| DPOE_SCHPO | cdc20 | physical | 25883047 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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