UniProt ID | SPT5_SCHPO | |
---|---|---|
UniProt AC | O13936 | |
Protein Name | Transcription elongation factor spt5 | |
Gene Name | spt5 | |
Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
Sequence Length | 990 | |
Subcellular Localization | Nucleus . | |
Protein Description | The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).. | |
Protein Sequence | MDTNSPKSIDKDANSTEVDAAEQDAASVKINSTRASPNGSDLLNDDSEAAKITTNEKQSSPVDSHNESPNDTTINKGEDGNENEVDNVNNNDKKEDEDNVEENEEEADANEEEEEDEEDDEEDEEDEDESGGGRRKRARHDRRNQFLDIEAEVDEDEEELEDEEDEIGREDGFIEEEVGADYVGDDRRHRELDRQRQELQSVDAERLAEEYREKYGRSQTVVGDTSNVPQRLLLPSVNDPNIWAVRCKIGKEKDIVFTIMRKAMDLQYTSSPLEIISAFQRDSLVGYIYVEARKQSHVLDALNGVLNVYTNNMILVPIKEMPDLLKVQKQVVELLPGAYVRIRRGKYAGDLAQVDNLSENGLTARVRIVPRIDYSDGLKRKNSATRPQARLFNESEAFKSNPSKFSKRGPRLFLFNNEEFEDGFLVKDIRISSLITEGVNPTLDEVSKFNPNNEDLDLSSLALSVKGGHAEFQPGDHVEVYVGEQTGVSGVVENVRGSVITMVSSDGLRLDVPSRGLRKRFRHGDYVKVIAGKYKDDTGMVVRISKDEVTFLSDTLMTELTVFSRDLGEASSAQAVNSAYELHDLVQLDVNTVACIFSVDRDTYKVIDQNGGVRTVLASQITMRHSNRRGVATDRNGAEIRIGDKVKEVGGEGKQGTILHIYRAFVFLHNRDIAENNGVFSARSRNVATIAAKGARISADLTKMNPALSNGPALPPVANLKRTIGRDKAIGATVRIRRGPMKGLLGVIKDTTDANARVELHTGNKMVTIPKENLLYTTKTGELISYTEFIERSRGIRPGSISTADGPNVPNWAQGARTPAVANGSRTPAWNTGSRTPAWNSGSKTPAWNSGSRTPAWNSGNKTPAWNAGSRTPAWNSGNKTPAWNVGNKTPAWNSGAKTPAWNAGNKTPSWNNGTKTPAWNANQTPMVANGTNTSWGQTPAYGGFSETNWDTEDNSKPYTAPTPGAWAAPTPGGWDDEEGDSPKYVPPSP | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
3 | Phosphorylation | -----MDTNSPKSID -----CCCCCCCCCC | 35.98 | 21712547 | |
5 | Phosphorylation | ---MDTNSPKSIDKD ---CCCCCCCCCCCC | 35.48 | 24763107 | |
8 | Phosphorylation | MDTNSPKSIDKDANS CCCCCCCCCCCCCCC | 39.13 | 28889911 | |
27 | Phosphorylation | AAEQDAASVKINSTR HHHHHHHCCEEECCC | 26.18 | 24763107 | |
32 | Phosphorylation | AASVKINSTRASPNG HHCCEEECCCCCCCH | 23.81 | 21712547 | |
33 | Phosphorylation | ASVKINSTRASPNGS HCCEEECCCCCCCHH | 26.26 | 28889911 | |
36 | Phosphorylation | KINSTRASPNGSDLL EEECCCCCCCHHHHC | 18.66 | 28889911 | |
40 | Phosphorylation | TRASPNGSDLLNDDS CCCCCCHHHHCCCCC | 31.55 | 29996109 | |
47 | Phosphorylation | SDLLNDDSEAAKITT HHHCCCCCHHHHCCC | 31.81 | 29996109 | |
53 | Phosphorylation | DSEAAKITTNEKQSS CCHHHHCCCCCCCCC | 23.90 | 21712547 | |
54 | Phosphorylation | SEAAKITTNEKQSSP CHHHHCCCCCCCCCC | 44.87 | 21712547 | |
59 | Phosphorylation | ITTNEKQSSPVDSHN CCCCCCCCCCCCCCC | 47.91 | 21712547 | |
60 | Phosphorylation | TTNEKQSSPVDSHNE CCCCCCCCCCCCCCC | 26.84 | 24763107 | |
64 | Phosphorylation | KQSSPVDSHNESPND CCCCCCCCCCCCCCC | 28.57 | 21712547 | |
68 | Phosphorylation | PVDSHNESPNDTTIN CCCCCCCCCCCCCCC | 34.03 | 21712547 | |
218 | Phosphorylation | YREKYGRSQTVVGDT HHHHHCCCCCCCCCC | 26.32 | 25720772 | |
818 | Phosphorylation | NWAQGARTPAVANGS CCCCCCCCCCCCCCC | 18.31 | 29996109 | |
825 | Phosphorylation | TPAVANGSRTPAWNT CCCCCCCCCCCCCCC | 32.56 | 29996109 | |
827 | Phosphorylation | AVANGSRTPAWNTGS CCCCCCCCCCCCCCC | 21.03 | 29996109 | |
836 | Phosphorylation | AWNTGSRTPAWNSGS CCCCCCCCCCCCCCC | 21.03 | 29996109 | |
845 | Phosphorylation | AWNSGSKTPAWNSGS CCCCCCCCCCCCCCC | 21.67 | 21712547 | |
850 | Phosphorylation | SKTPAWNSGSRTPAW CCCCCCCCCCCCCCC | 27.69 | 21712547 | |
852 | Phosphorylation | TPAWNSGSRTPAWNS CCCCCCCCCCCCCCC | 32.57 | 27738172 | |
854 | Phosphorylation | AWNSGSRTPAWNSGN CCCCCCCCCCCCCCC | 21.03 | 24763107 | |
863 | Phosphorylation | AWNSGNKTPAWNAGS CCCCCCCCCCCCCCC | 23.41 | 21712547 | |
870 | Phosphorylation | TPAWNAGSRTPAWNS CCCCCCCCCCCCCCC | 30.48 | 21712547 | |
872 | Phosphorylation | AWNAGSRTPAWNSGN CCCCCCCCCCCCCCC | 21.03 | 24763107 | |
877 | Phosphorylation | SRTPAWNSGNKTPAW CCCCCCCCCCCCCCC | 32.80 | 21712547 | |
881 | Phosphorylation | AWNSGNKTPAWNVGN CCCCCCCCCCCCCCC | 23.41 | 24763107 | |
890 | Phosphorylation | AWNVGNKTPAWNSGA CCCCCCCCCCCCCCC | 23.41 | 24763107 | |
899 | Phosphorylation | AWNSGAKTPAWNAGN CCCCCCCCCCCCCCC | 20.08 | 24763107 | |
908 | Phosphorylation | AWNAGNKTPSWNNGT CCCCCCCCCCCCCCC | 26.93 | 21712547 | |
910 | Phosphorylation | NAGNKTPSWNNGTKT CCCCCCCCCCCCCCC | 47.90 | 24763107 | |
915 | Phosphorylation | TPSWNNGTKTPAWNA CCCCCCCCCCCCCCC | 33.59 | 24763107 | |
963 | Phosphorylation | SKPYTAPTPGAWAAP CCCCCCCCCCCCCCC | 31.71 | 24763107 | |
971 | Phosphorylation | PGAWAAPTPGGWDDE CCCCCCCCCCCCCCC | 29.82 | 24763107 | |
982 | Phosphorylation | WDDEEGDSPKYVPPS CCCCCCCCCCCCCCC | 33.86 | 24763107 | |
985 | Phosphorylation | EEGDSPKYVPPSP-- CCCCCCCCCCCCC-- | 22.90 | 27738172 | |
989 | Phosphorylation | SPKYVPPSP------ CCCCCCCCC------ | 0.00 | 21712547 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPT5_SCHPO !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPT5_SCHPO !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPT5_SCHPO !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
MCE1_SCHPO | ceg1 | physical | 11893740 | |
CET1_SCHPO | pct1 | physical | 11893740 | |
CET1_SCHPO | pct1 | genetic | 20231361 | |
MCE1_SCHPO | ceg1 | genetic | 20231361 | |
GEMI4_HUMAN | GEMIN4 | genetic | 20231361 | |
RPB1_SCHPO | rpb1 | genetic | 20231361 | |
SET1_SCHPO | set1 | genetic | 22876190 | |
RTF1_SCHPO | prf1 | physical | 24385927 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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