F217B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F217B_HUMAN
• UniProt AC: Q9NTX9
• Protein Name: Protein FAM217B
• Gene Name: FAM217B
• Organism: Homo sapiens (Human).
• Sequence Length: 383
• Protein Sequence: MNAGPSWNKVQHSKNSSGKRQSKSQVPHASSQPRSSLTAVTQPTEEKLKESISPEARRKRNPLGSRCQGASGNKLFLDFQSMKIIKENADEDSASDLSDSERIPIPPSPLTPPDLNLRAEEIDPVYFDLHPGQGHTKPEYYYPNFLPSPFSSWDLRDMALLLNAENKTEAVPRVGGLLGKYIDRLIQLEWLQVQTVQCEKAKGGKARPPTAPGTSGALKSPGRSKLIASALSKPLPHQEGASKSGPSRKKAFHHEEIHPSHYAFETSPRPIDVLGGTRFCSQRQTLEMRTEEKKKKSSKSTKLQRWDLSGSGSSSKVETSGHIRVPKQAAVILDSADSCKASKTQAHAHPRKKGKAESCGHATVSSEKKLKTNGVKQNTYKLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MNAGPSWNKVQHS --CCCCCCCCCCCCC	42.22	29978859
13	Phosphorylation	SWNKVQHSKNSSGKR CCCCCCCCCCCCCCC	19.21	29978859
16	Phosphorylation	KVQHSKNSSGKRQSK CCCCCCCCCCCCCCH	44.17	29978859
17	Phosphorylation	VQHSKNSSGKRQSKS CCCCCCCCCCCCCHH	58.70	29978859
24	Phosphorylation	SGKRQSKSQVPHASS CCCCCCHHHCCCCCC	41.48	27251275
49	Ubiquitination	QPTEEKLKESISPEA CCCHHHHHHHCCHHH	61.56	-
51	Phosphorylation	TEEKLKESISPEARR CHHHHHHHCCHHHHH	27.12	29255136
53	Phosphorylation	EKLKESISPEARRKR HHHHHHCCHHHHHHH	26.43	29255136
81	Phosphorylation	KLFLDFQSMKIIKEN CEEEEHHHHHHHHHC	23.26	22468782
95	Phosphorylation	NADEDSASDLSDSER CCCCCCHHHCCCCCC	42.93	22468782
100	Phosphorylation	SASDLSDSERIPIPP CHHHCCCCCCCCCCC	25.96	22468782
111	Phosphorylation	PIPPSPLTPPDLNLR CCCCCCCCCCCCCCC	35.84	24076635
232	Phosphorylation	KLIASALSKPLPHQE HHHHHHHCCCCCCCC	31.76	24719451
244	Phosphorylation	HQEGASKSGPSRKKA CCCCCCCCCCCHHHC	54.14	-
290	Phosphorylation	RQTLEMRTEEKKKKS HHHHHHHHHHHHHHC	47.38	-
311	Phosphorylation	QRWDLSGSGSSSKVE EEEECCCCCCCCCEE	31.93	22210691
313	Phosphorylation	WDLSGSGSSSKVETS EECCCCCCCCCEEEC	32.89	22210691
319	Phosphorylation	GSSSKVETSGHIRVP CCCCCEEECCCCCCC	42.89	22210691
363	Phosphorylation	AESCGHATVSSEKKL HHHCCCCCCCCHHHH	18.42	-
376	Acetylation	KLKTNGVKQNTYKLK HHHCCCCCCCCEECC	38.95	23749302

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F217B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F217B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F217B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD209_HUMAN	CD209	physical	26186194
ICK_HUMAN	ICK	physical	26186194
BLK_HUMAN	BLK	physical	26186194
NCK1_HUMAN	NCK1	physical	26186194
NCK2_HUMAN	NCK2	physical	26186194
RB11B_HUMAN	RAB11B	physical	26186194
CALR3_HUMAN	CALR3	physical	26186194
NEUR2_HUMAN	NEU2	physical	26186194
DUS6_HUMAN	DUSP6	physical	26186194
RFIP1_HUMAN	RAB11FIP1	physical	26186194
NEUR2_HUMAN	NEU2	physical	28514442
CD209_HUMAN	CD209	physical	28514442
CALR3_HUMAN	CALR3	physical	28514442
NCK2_HUMAN	NCK2	physical	28514442
DUS6_HUMAN	DUSP6	physical	28514442
RB11B_HUMAN	RAB11B	physical	28514442
NCK1_HUMAN	NCK1	physical	28514442
ICK_HUMAN	ICK	physical	28514442
BLK_HUMAN	BLK	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.