| UniProt ID | CALR3_HUMAN | |
|---|---|---|
| UniProt AC | Q96L12 | |
| Protein Name | Calreticulin-3 | |
| Gene Name | CALR3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 384 | |
| Subcellular Localization | Endoplasmic reticulum lumen . | |
| Protein Description | During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calcium-binding may be absent or much lower than that of CALR.. | |
| Protein Sequence | MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHKEKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQKNLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDLSYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKINRHEHYFNQFHRRNEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 42 | N-linked_Glycosylation | NRWLQSTNDSRFGHF HHHCCCCCCCCCCEE | 50.97 | UniProtKB CARBOHYD | |
| 57 | Phosphorylation | RLSSGKFYGHKEKDK EECCCCCCCCCCCCC | 23.08 | - | |
| 68 | Phosphorylation | EKDKGLQTTQNGRFY CCCCCCEECCCCEEE | 35.08 | 22210691 | |
| 69 | Phosphorylation | KDKGLQTTQNGRFYA CCCCCEECCCCEEEE | 13.69 | 28555341 | |
| 78 | Phosphorylation | NGRFYAISARFKPFS CCEEEEEEEEEEECC | 12.76 | 22210691 | |
| 89 | Acetylation | KPFSNKGKTLVIQYT EECCCCCCEEEEEEE | 40.05 | 7976105 | |
| 201 | N-linked_Glycosylation | GSIEYDWNLTSLKKE CEEEEEEECCCCCCC | 30.46 | UniProtKB CARBOHYD | |
| 209 | Phosphorylation | LTSLKKETSPAESKD CCCCCCCCCCCCCCC | 49.22 | - | |
| 210 | Phosphorylation | TSLKKETSPAESKDW CCCCCCCCCCCCCCH | 24.17 | - | |
| 214 | Phosphorylation | KETSPAESKDWEQTK CCCCCCCCCCHHHHC | 37.71 | - | |
| 230 | Acetylation | NKAQDWEKHFLDAST CCHHHHHHHCCCCCC | 35.09 | 20167786 | |
| 374 | Phosphorylation | KINRHEHYFNQFHRR CCHHHHHHHHHHHHH | 10.97 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CALR3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CALR3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CALR3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| UBR5_HUMAN | UBR5 | physical | 26186194 | |
| FAT1_HUMAN | FAT1 | physical | 26186194 | |
| OS9_HUMAN | OS9 | physical | 26186194 | |
| GPR98_HUMAN | GPR98 | physical | 26186194 | |
| ITA8_HUMAN | ITGA8 | physical | 26186194 | |
| FREM2_HUMAN | FREM2 | physical | 26186194 | |
| CLN5_HUMAN | CLN5 | physical | 26186194 | |
| T132A_HUMAN | TMEM132A | physical | 26186194 | |
| UBR5_HUMAN | UBR5 | physical | 28514442 | |
| GPR98_HUMAN | GPR98 | physical | 28514442 | |
| ITA8_HUMAN | ITGA8 | physical | 28514442 | |
| T132A_HUMAN | TMEM132A | physical | 28514442 | |
| CLN5_HUMAN | CLN5 | physical | 28514442 | |
| TXD16_HUMAN | TXNDC16 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 613875 | Cardiomyopathy, familial hypertrophic 19 (CMH19) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
