F16B2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F16B2_HUMAN
• UniProt AC: Q86V87
• Protein Name: Protein FAM160B2
• Gene Name: FAM160B2
• Organism: Homo sapiens (Human).
• Sequence Length: 743
• Protein Sequence: MLSRLGALLQEAVGAREPSIDLLQAFVEHWKGITHYYIESTDESTPAKKTDIPWRLKQMLDILVYEEQQQAAAGEAGPCLEYLLQHKILETLCTLGKAEYPPGMRQQVFQFFSKVLAQVQHPLLHYLSVHRPVQKLLRLGGTASGSVTEKEEVQFTTVLCSKIQQDPELLAYILEGKKIVGRKKACGEPTALPKDTTSHGDKDCSHDGAPARPQLDGESCGAQALNSHMPAETEELDGGTTESNLITSLLGLCQSKKSRVALKAQENLLLLVSMASPAAATYLVQSSACCPAIVRHLCQLYRSMPVFLDPADIATLEGISWRLPSAPSDEASFPGKEALAAFLGWFDYCDHLITEAHTVVADALAKAVAENFFVETLQPQLLHVSEQSILTSTALLTAMLRQLRSPALLREAVAFLLGTDRQPEAPGDNPHTLYAHLIGHCDHLSDEISITTLRLFEELLQKPHEGIIHSLVLRNLEGRPYVAWGSPEPESYEDTLDLEEDPYFTDSFLDSGFQTPAKPRLAPATSYDGKTAVTEIVNSFLCLVPEEAKTSAFLEETGYDTYVHDAYGLFQECSSRVASWGWPLTPTPLDPHEPERPFFEGHFLRVLFDRMSRILDQPYSLNLQVTSVLSRLALFPHPHIHEYLLDPYISLAPGCRSLFSVLVRVIGDLMQRIQRVPQFPGKLLLVRKQLTGQAPGEQLDHQTLLQGVVVLEEFCKELAAIAFVKFPPHDPRQNVSPAPEGQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	WKGITHYYIESTDES CCCCCEEEEEECCCC	7.21	27642862
40	Phosphorylation	ITHYYIESTDESTPA CCEEEEEECCCCCCC	31.44	-
177	Ubiquitination	LAYILEGKKIVGRKK HHHHHCCCEEECCCC	29.92	29967540
202	Acetylation	DTTSHGDKDCSHDGA CCCCCCCCCCCCCCC	66.29	19811809
320	Phosphorylation	IATLEGISWRLPSAP HHHHCCCCEECCCCC	19.59	24719451
325	Phosphorylation	GISWRLPSAPSDEAS CCCEECCCCCCCCCC	58.36	-
391	Phosphorylation	VSEQSILTSTALLTA CCHHHHHHHHHHHHH	23.51	-
397	Phosphorylation	LTSTALLTAMLRQLR HHHHHHHHHHHHHCC	15.75	-
503	Phosphorylation	LDLEEDPYFTDSFLD CCCCCCCCCCHHHHH	31.28	27642862
525	Phosphorylation	KPRLAPATSYDGKTA CCCCCCCCCCCCCHH	27.10	26657352
526	Phosphorylation	PRLAPATSYDGKTAV CCCCCCCCCCCCHHH	24.27	25159151
527	Phosphorylation	RLAPATSYDGKTAVT CCCCCCCCCCCHHHH	25.10	28857561
585	Phosphorylation	ASWGWPLTPTPLDPH HHCCCCCCCCCCCCC	22.49	27273156
612	Phosphorylation	RVLFDRMSRILDQPY HHHHHHHHHHHCCCC	19.64	-
736	Phosphorylation	HDPRQNVSPAPEGQV CCCCCCCCCCCCCCC	23.93	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
325	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F16B2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F16B2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
DYHC2_HUMAN	DYNC2H1	physical	26186194
RECQ4_HUMAN	RECQL4	physical	26186194
ZN318_HUMAN	ZNF318	physical	26186194
SMG8_HUMAN	SMG8	physical	26186194
ZN318_HUMAN	ZNF318	physical	28514442
MYO5A_HUMAN	MYO5A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.