| UniProt ID | ENDOV_HUMAN | |
|---|---|---|
| UniProt AC | Q8N8Q3 | |
| Protein Name | Endonuclease V | |
| Gene Name | ENDOV | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 282 | |
| Subcellular Localization | Cytoplasm. Nucleus, nucleolus. | |
| Protein Description | Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.. | |
| Protein Sequence | MALEAAGGPPEETLSLWKREQARLKAHVVDRDTEAWQRDPAFSGLQRVGGVDVSFVKGDSVRACASLVVLSFPELEVVYEESRMVSLTAPYVSGFLAFREVPFLLELVQQLREKEPGLMPQVLLVDGNGVLHHRGFGVACHLGVLTDLPCVGVAKKLLQVDGLENNALHKEKIRLLQTRGDSFPLLGDSGTVLGMALRSHDRSTRPLYISVGHRMSLEAAVRLTCCCCRFRIPEPVRQADICSREHIRKSLGLPGPPTPRSPKAQRPVACPKGDSGESSALC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 18 | Ubiquitination | EETLSLWKREQARLK HHHHHHHHHHHHHHH | 51.88 | - | |
| 25 | Ubiquitination | KREQARLKAHVVDRD HHHHHHHHCEEECCC | 30.78 | - | |
| 57 | Ubiquitination | GVDVSFVKGDSVRAC CEEEEEECCHHHHHH | 55.80 | 2190698 | |
| 57 (in isoform 3) | Ubiquitination | - | 55.80 | 21906983 | |
| 57 (in isoform 2) | Ubiquitination | - | 55.80 | 21906983 | |
| 57 (in isoform 1) | Ubiquitination | - | 55.80 | 21906983 | |
| 86 | Phosphorylation | YEESRMVSLTAPYVS EEECCEEECCCCCCC | 15.62 | 28122231 | |
| 88 | Phosphorylation | ESRMVSLTAPYVSGF ECCEEECCCCCCCCC | 20.34 | 28122231 | |
| 146 | Phosphorylation | ACHLGVLTDLPCVGV CHHHCCCCCCCCHHH | 32.84 | - | |
| 156 | Ubiquitination | PCVGVAKKLLQVDGL CCHHHHHHHHHCCCC | 44.70 | - | |
| 170 | Ubiquitination | LENNALHKEKIRLLQ CCCCCHHHHHHHHHH | 62.65 | - | |
| 172 | Ubiquitination | NNALHKEKIRLLQTR CCCHHHHHHHHHHHC | 37.62 | - | |
| 178 | Phosphorylation | EKIRLLQTRGDSFPL HHHHHHHHCCCCCCC | 36.27 | - | |
| 182 | Phosphorylation | LLQTRGDSFPLLGDS HHHHCCCCCCCCCCC | 31.43 | - | |
| 198 | Methylation | TVLGMALRSHDRSTR CHHHHHHHCCCCCCC | 23.54 | - | |
| 198 | Dimethylation | TVLGMALRSHDRSTR CHHHHHHHCCCCCCC | 23.54 | - | |
| 202 | Methylation | MALRSHDRSTRPLYI HHHHCCCCCCCCEEE | 34.21 | - | |
| 202 | Dimethylation | MALRSHDRSTRPLYI HHHHCCCCCCCCEEE | 34.21 | - | |
| 230 (in isoform 3) | Phosphorylation | - | 5.32 | 25159151 | |
| 233 (in isoform 3) | Phosphorylation | - | 35.27 | 25627689 | |
| 244 (in isoform 3) | Phosphorylation | - | 34.79 | 25849741 | |
| 250 | Phosphorylation | SREHIRKSLGLPGPP CHHHHHHHCCCCCCC | 20.16 | 23403867 | |
| 258 | Phosphorylation | LGLPGPPTPRSPKAQ CCCCCCCCCCCCCCC | 34.17 | 25159151 | |
| 261 | Phosphorylation | PGPPTPRSPKAQRPV CCCCCCCCCCCCCCC | 31.77 | 25159151 | |
| 278 | Phosphorylation | PKGDSGESSALC--- CCCCCCCCCCCC--- | 25.16 | - | |
| 279 | Phosphorylation | KGDSGESSALC---- CCCCCCCCCCC---- | 22.43 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ENDOV_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ENDOV_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ENDOV_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| BBS2_HUMAN | BBS2 | physical | 26186194 | |
| VWA8_HUMAN | VWA8 | physical | 26186194 | |
| TCPB_HUMAN | CCT2 | physical | 26186194 | |
| ANR40_HUMAN | ANKRD40 | physical | 26186194 | |
| PHLP_HUMAN | PDCL | physical | 26186194 | |
| SPS2_HUMAN | SEPHS2 | physical | 26186194 | |
| RNF31_HUMAN | RNF31 | physical | 26186194 | |
| T22D3_HUMAN | TSC22D3 | physical | 26186194 | |
| APAF_HUMAN | APAF1 | physical | 26186194 | |
| SPS2_HUMAN | SEPHS2 | physical | 28514442 | |
| APAF_HUMAN | APAF1 | physical | 28514442 | |
| RNF31_HUMAN | RNF31 | physical | 28514442 | |
| VWA8_HUMAN | VWA8 | physical | 28514442 | |
| T22D3_HUMAN | TSC22D3 | physical | 28514442 | |
| ANR40_HUMAN | ANKRD40 | physical | 28514442 | |
| PHLP_HUMAN | PDCL | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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