E2AK1_SCHPO - dbPTM
E2AK1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID E2AK1_SCHPO
UniProt AC O13889
Protein Name Eukaryotic translation initiation factor 2-alpha kinase 1
Gene Name hri1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 704
Subcellular Localization
Protein Description Mediates down-regulation of protein synthesis in response to stress conditions by the phosphorylation of the alpha subunit of eIF-2 (tif211) on 'Ser-52'. Protein synthesis is inhibited at the level of initiation. Activity is inhibited in the presence of heme..
Protein Sequence MLGTSTKCSKRDCNYAKENISRIMPTIGLGYKQNFEKKTADTQSSCKLLLVALLESFCKHSDQTPEQSKQMFLYVAHSLQNSGIIDFEFSEELEPIRNAYADSLHNLLSKAFRSTLPMSSTKDSKKSRYSSPDGVLAKTASFLSVLSDGGYEDDVMNVKPSVNVLSNRLNHLPVEALESCFPQTTLESSTFADFCEHKDGTGNLSFSNFDSFPTVQRSRYASDFEELELLGKGGYGSVYKARNKFDGVEYALKKIPLRLRSFSTSSNIFRESRTLARLNHPNVIRFFSSWVELLPSSEKQIEEEPLASADETLSQSADIDNFMFDMDTGLLQHTYPSSVQILFQEDSVADDLTPCYSTKNSTCNLTDLFKKEADQDYAESHDCSSTTSQVDTLGKLAPTKSASEMLLMDSFLSEREEDECSNIPSFDQQPLCLYIQMALCEETLEKHINRRNKHIHGVMSKGLRNCYILLFARILEGVLYLHDAMHLVHRDLKPRNIFLSSGVHSEPCSVCLPNFSDEDNVEVSNAYEPVNQRTLCVVPKIGDFGLVLSQSDNLEEGTNSSAESSFVGTSTYAAPELFSKHMRSVMNNNSSTDIYALGILFFELLYPFNTRMERASAIANLKKGIFPHDFLDSMPEEASLIRSMLSSSNKRPTAAQLLTSNLFHDLVVNELHVYQALLEDAEKRNNNLKAELNILRVLNPNYDC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
129PhosphorylationKDSKKSRYSSPDGVL
CCCCCCCCCCCCCHH		22.1625720772
205PhosphorylationKDGTGNLSFSNFDSF
CCCCCCCCCCCCCCC		30.5425720772
380PhosphorylationADQDYAESHDCSSTT
HCHHHHHHCCCCCCH		19.2225720772
384PhosphorylationYAESHDCSSTTSQVD
HHHHCCCCCCHHHCC		36.4625720772
385PhosphorylationAESHDCSSTTSQVDT
HHHCCCCCCHHHCCC		41.8725720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of E2AK1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of E2AK1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of E2AK1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IF2A_SCHPOtif211physical
12242291
SRB11_SCHPOsrb11genetic
18818364
POM1_SCHPOpom1genetic
18818364
ABP1_SCHPOcbp1genetic
18818364
YC8F_SCHPOSPCC622.15cgenetic
18818364
YCRE_SCHPOtrs130genetic
22681890
THI9_SCHPOthi9genetic
22681890
YJ52_SCHPOSPCP20C8.02cgenetic
22681890
ARF6_SCHPOarf6genetic
22681890
MIC60_SCHPOSPBC3E7.05cgenetic
22681890
YAOF_SCHPOSPAC11D3.15genetic
22681890
MSA1_SCHPOmsa1genetic
22681890
YL8H_SCHPOSPAC25B8.17genetic
22681890
YOI9_SCHPOSPBC1778.09genetic
22681890
ATP5E_SCHPOatp15genetic
22681890
RL16B_SCHPOrpl1601genetic
22681890
VPS20_SCHPOvps20genetic
22681890
FFT3_SCHPOfft3genetic
22681890
RL10B_SCHPOrpl1002genetic
22681890
YHZ3_SCHPOath1genetic
22681890
MDM31_SCHPOmdm31genetic
22681890
RL19B_SCHPOrpl1902genetic
22681890
GCN2_SCHPOgcn2genetic
23687372
ATG11_SCHPOatg11physical
26771498
IF2A_SCHPOtif211physical
19880757
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of E2AK1_SCHPO

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Related Literatures of Post-Translational Modification

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