COLQ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COLQ_HUMAN
• UniProt AC: Q9Y215
• Protein Name: Acetylcholinesterase collagenic tail peptide
• Gene Name: COLQ
• Organism: Homo sapiens (Human).
• Sequence Length: 455
• Subcellular Localization: Cell junction, synapse.
• Protein Description: Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina..
• Protein Sequence: MVVLNPMTLGIYLQLFFLSIVSQPTFINSVLPISAALPSLDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPGRKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKGEPGIAGHRGPTGRPGKRGKQGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDFGYLTCETYLPGSYGDLQCTQYCYIDSTPCRYFT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Phosphorylation	CMQGSLGSPGPPGPQ CCCCCCCCCCCCCCC	31.79	-
116	Phosphorylation	PPGLPGKTGPKGEKG CCCCCCCCCCCCCCC	65.71	22210691
157	Ubiquitination	GPEGPRGEKGDLGMM CCCCCCCCCCCCCCC	55.96	20972266
169	Phosphorylation	GMMGLPGSRGPMGSK CCCCCCCCCCCCCCC	31.93	-
175	Phosphorylation	GSRGPMGSKGYPGSR CCCCCCCCCCCCCCC	19.36	-
178	Phosphorylation	GPMGSKGYPGSRGEK CCCCCCCCCCCCCCC	14.25	-
181	Phosphorylation	GSKGYPGSRGEKGSR CCCCCCCCCCCCCCC	32.38	-
181	Ubiquitination	GSKGYPGSRGEKGSR CCCCCCCCCCCCCCC	32.38	20972266
182	Methylation	SKGYPGSRGEKGSRG CCCCCCCCCCCCCCC	64.30	-
191	Ubiquitination	EKGSRGEKGDLGPKG CCCCCCCCCCCCCCC	61.62	2097226
312	Phosphorylation	GESVYGPSSPRVPVI CCCCCCCCCCCCCEE	48.92	26853621
313	Phosphorylation	ESVYGPSSPRVPVIF CCCCCCCCCCCCEEE	21.62	26853621

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COLQ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COLQ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COLQ_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P3H2_HUMAN	P3H2	physical	28514442
FINC_HUMAN	FN1	physical	28514442
TRI68_HUMAN	TRIM68	physical	28514442
P3H3_HUMAN	LEPREL2	physical	28514442
CHLE_HUMAN	BCHE	physical	28514442
CRTAP_HUMAN	CRTAP	physical	28514442
GT252_HUMAN	COLGALT2	physical	28514442
FBLN1_HUMAN	FBLN1	physical	28514442
SC65_HUMAN	P3H4	physical	28514442
PLOD1_HUMAN	PLOD1	physical	28514442
PLOD2_HUMAN	PLOD2	physical	28514442
P4HA1_HUMAN	P4HA1	physical	28514442
P3H1_HUMAN	P3H1	physical	28514442
TEX15_HUMAN	TEX15	physical	28514442
CO4A2_HUMAN	COL4A2	physical	28514442
RPB1_HUMAN	POLR2A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 603034: Myasthenic syndrome, congenital, 5 (CMS5)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.