AQP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AQP5_HUMAN
• UniProt AC: P55064
• Protein Name: Aquaporin-5
• Gene Name: AQP5
• Organism: Homo sapiens (Human).
• Sequence Length: 265
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein .
• Protein Description: Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. [PubMed: 16571723 Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells]
• Protein Sequence: MKKEVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPVSGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALNNNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTYEPDEDWEEQREERKKTMELTTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	S-palmitoylation	--MKKEVCSVAFLKA --CCHHHHHHHHHHH	2.58	30489624
7	Phosphorylation	-MKKEVCSVAFLKAV -CCHHHHHHHHHHHH	22.96	23401153
124	N-linked_Glycosylation	LAVNALNNNTTQGQA EEHHHCCCCCCHHHH	48.34	UniProtKB CARBOHYD
125	N-linked_Glycosylation	AVNALNNNTTQGQAM EHHHCCCCCCHHHHH	43.35	UniProtKB CARBOHYD
156	Phosphorylation	STDSRRTSPVGSPAL CCCCCCCCCCCCCCH	18.77	18478076
183	Phosphorylation	GIYFTGCSMNPARSF HHHHCCCCCCCCHHC	23.96	-
233	Phosphorylation	FPNSLSLSERVAIIK CCCCCCHHHCEEHHC	21.71	24719451
243	Phosphorylation	VAIIKGTYEPDEDWE EEHHCCCCCCCCCHH	33.85	22817900
258	Acetylation	EQREERKKTMELTTR HHHHHHHHHHHHCCC	60.36	7681295
259	Phosphorylation	QREERKKTMELTTR- HHHHHHHHHHHCCC-	20.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
156	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AQP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AQP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDFI_HUMAN	MDFI	physical	16189514
MDFI_HUMAN	MDFI	physical	19060904
GLRX1_HUMAN	GLRX	physical	21988832
WNT2_HUMAN	WNT2	physical	21988832
HNRPK_HUMAN	HNRNPK	physical	25416956
K1H1_HUMAN	KRT31	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 600231: Keratoderma, palmoplantar, Bothnian type (PPKB)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.