WNT2_HUMAN - dbPTM
WNT2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WNT2_HUMAN
UniProt AC P09544
Protein Name Protein Wnt-2
Gene Name WNT2
Organism Homo sapiens (Human).
Sequence Length 360
Subcellular Localization Secreted, extracellular space, extracellular matrix . Secreted .
Protein Description Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. [PubMed: 20018874 Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity]
Protein Sequence MNAPLGGIWLWLPLLLTWLTPEVNSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGEVKSCSCDPKKMGSAKDSKGIFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCGCKFHWCCAVRCQDCLEALDVHTCKAPKNADWTTAT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
112PhosphorylationSRESAFVYAISSAGV
CCCHHHHHEECCCCH
7.55-
115PhosphorylationSAFVYAISSAGVVFA
HHHHHEECCCCHHHE
13.13-
124PhosphorylationAGVVFAITRACSQGE
CCHHHEEEECCCCCC
14.58-
158PhosphorylationIFDWGGCSDNIDYGI
CCCCCCCCCCHHHHH
36.6524719451
163PhosphorylationGCSDNIDYGIKFARA
CCCCCHHHHHHHHHH
19.5624719451
212O-palmitoleoylationECKCHGVSGSCTLRT
HHCCCCCCCCHHHHH
29.58-
229"N6,N6-dimethyllysine"LAMADFRKTGDYLWR
HHHCHHHHHCHHHHH
57.78-
229MethylationLAMADFRKTGDYLWR
HHHCHHHHHCHHHHH
57.78-
295N-linked_GlycosylationGTAGRVCNLTSRGMD
CCCHHHHCCCCCCCC
43.42UniProtKB CARBOHYD
319PhosphorylationGYDTSHVTRMTKCGC
CCCCHHHCHHCCCCC
14.8622985185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WNT2_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WNT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WNT2_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SFRP1_HUMANSFRP1physical
10347172
NDK7_HUMANNME7physical
26186194
GRP78_HUMANHSPA5physical
28514442

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WNT2_HUMAN

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Related Literatures of Post-Translational Modification

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