UniProt ID | WNT2_HUMAN | |
---|---|---|
UniProt AC | P09544 | |
Protein Name | Protein Wnt-2 | |
Gene Name | WNT2 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 360 | |
Subcellular Localization | Secreted, extracellular space, extracellular matrix . Secreted . | |
Protein Description | Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. [PubMed: 20018874 Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity] | |
Protein Sequence | MNAPLGGIWLWLPLLLTWLTPEVNSSWWYMRATGGSSRVMCDNVPGLVSSQRQLCHRHPDVMRAISQGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFAITRACSQGEVKSCSCDPKKMGSAKDSKGIFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFLKQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVANERFKKPTKNDLVYFENSPDYCIRDREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCGCKFHWCCAVRCQDCLEALDVHTCKAPKNADWTTAT | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
112 | Phosphorylation | SRESAFVYAISSAGV CCCHHHHHEECCCCH | 7.55 | - | |
115 | Phosphorylation | SAFVYAISSAGVVFA HHHHHEECCCCHHHE | 13.13 | - | |
124 | Phosphorylation | AGVVFAITRACSQGE CCHHHEEEECCCCCC | 14.58 | - | |
158 | Phosphorylation | IFDWGGCSDNIDYGI CCCCCCCCCCHHHHH | 36.65 | 24719451 | |
163 | Phosphorylation | GCSDNIDYGIKFARA CCCCCHHHHHHHHHH | 19.56 | 24719451 | |
212 | O-palmitoleoylation | ECKCHGVSGSCTLRT HHCCCCCCCCHHHHH | 29.58 | - | |
229 | "N6,N6-dimethyllysine" | LAMADFRKTGDYLWR HHHCHHHHHCHHHHH | 57.78 | - | |
229 | Methylation | LAMADFRKTGDYLWR HHHCHHHHHCHHHHH | 57.78 | - | |
295 | N-linked_Glycosylation | GTAGRVCNLTSRGMD CCCHHHHCCCCCCCC | 43.42 | UniProtKB CARBOHYD | |
319 | Phosphorylation | GYDTSHVTRMTKCGC CCCCHHHCHHCCCCC | 14.86 | 22985185 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WNT2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WNT2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WNT2_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
SFRP1_HUMAN | SFRP1 | physical | 10347172 | |
NDK7_HUMAN | NME7 | physical | 26186194 | |
GRP78_HUMAN | HSPA5 | physical | 28514442 |
Kegg Drug | ||||||
---|---|---|---|---|---|---|
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...