AMPH_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AMPH_RAT
• UniProt AC: O08838
• Protein Name: Amphiphysin
• Gene Name: Amph
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 683
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
• Protein Description: May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity)..
• Protein Sequence: MADIKTGIFAKNVQKRLNRAQEKVLQKLGKADETKDEQFEEYVQNFKRQEAEGTRLQRELRGYLAAIKGMQEASMKLTESLHEVYEPDWYGREDVKMVGEKCDVLWEDFHQKLVDGSLLTLDTYLGQFPDIKNRIAKRSRKLVDYDSARHHLEALQSSKRKDESRISKAEEEFQKAQKVFEEFNVDLQEELPSLWSRRVGFYVNTFKNVSSLEAKFHKEIAVLCHKLYEVMTKLGDQHADKAFSIQGAPSDSGPLRIAKTPSPPEEASPLPSPTASPNHTLAPASPAPVRPRSPSQTRKGPPVPPLPKVTPTKELQQENIINFFEDNFVPEINVTTPSQNEVLEVKKEETLLDLDFDPFKPDVTPAGSAAATHSPMSQTLPWDLWTTSTDLVQPASGGSFNDFTQPQDTSLFTMQTDQNMAETEQALPTEPQAEEPPTTAAAPTAGLDLGLEMEEPKEEAAIPPGTDAGETVGTEGSTGEEAEAEKAALPAGEGESPEGAKIDVESTELASSESPQAAELEAGAPQEKVIPSVVIEPASNHEGEEHQETTTGTETREATEDVAPQGPAGEKQELATEPTPLDSQAATPAPAGAVDASLSAGDAAQELPPGFLYKVETLHDFEAANSDELTLQRGDVVLVVPSDSEADQDAGWLVGVKESDWLQYRDLATYKGLFPENFTRHLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Acetylation	EEYVQNFKRQEAEGT HHHHHHHHHHHHHHH	61.80	22902405
141	Acetylation	RIAKRSRKLVDYDSA HHHHHHHHHCCHHHH	54.85	72588173
159	Ubiquitination	LEALQSSKRKDESRI HHHHHHCCCCCHHHH	69.57	-
168	Acetylation	KDESRISKAEEEFQK CCHHHHHHHHHHHHH	58.40	22902405
215	Acetylation	NVSSLEAKFHKEIAV CHHHHHHHHHHHHHH	38.33	22902405
233	Acetylation	KLYEVMTKLGDQHAD HHHHHHHHHCHHHCC	32.17	22902405
250	Phosphorylation	FSIQGAPSDSGPLRI EEECCCCCCCCCCCE	43.82	25403869
252	Phosphorylation	IQGAPSDSGPLRIAK ECCCCCCCCCCCEEE	46.80	30411139
260	Phosphorylation	GPLRIAKTPSPPEEA CCCCEEECCCCCHHC	21.70	27097102
262	Phosphorylation	LRIAKTPSPPEEASP CCEEECCCCCHHCCC	59.32	27097102
268	Phosphorylation	PSPPEEASPLPSPTA CCCCHHCCCCCCCCC	30.19	27097102
272	Phosphorylation	EEASPLPSPTASPNH HHCCCCCCCCCCCCC	42.43	27097102
274	Phosphorylation	ASPLPSPTASPNHTL CCCCCCCCCCCCCCC	44.07	27097102
276	Phosphorylation	PLPSPTASPNHTLAP CCCCCCCCCCCCCCC	28.81	27097102
280	Phosphorylation	PTASPNHTLAPASPA CCCCCCCCCCCCCCC	31.12	28432305
285	Phosphorylation	NHTLAPASPAPVRPR CCCCCCCCCCCCCCC	22.12	27097102
293	Phosphorylation	PAPVRPRSPSQTRKG CCCCCCCCCCCCCCC	31.42	18344231
310	Phosphorylation	VPPLPKVTPTKELQQ CCCCCCCCCCHHHHH	31.22	30240740
496	Phosphorylation	LPAGEGESPEGAKID CCCCCCCCCCCCEEE	38.82	25403869
506	Phosphorylation	GAKIDVESTELASSE CCEEEECCCCCCCCC	27.34	28551015
507	Phosphorylation	AKIDVESTELASSES CEEEECCCCCCCCCC	22.85	28551015
511	Phosphorylation	VESTELASSESPQAA ECCCCCCCCCCCCHH	47.46	25403869
512	Phosphorylation	ESTELASSESPQAAE CCCCCCCCCCCCHHH	36.16	25403869
514	Phosphorylation	TELASSESPQAAELE CCCCCCCCCCHHHHC	25.02	30240740
532	Phosphorylation	PQEKVIPSVVIEPAS CCCCCCCEEEEEECC	20.21	28551015
539	Phosphorylation	SVVIEPASNHEGEEH EEEEEECCCCCCCCC	49.81	30411139
626	Phosphorylation	HDFEAANSDELTLQR HHHHHCCCCCCEECC	27.95	18344231
671	Ubiquitination	YRDLATYKGLFPENF HHHHHHHCCCCCCCH	44.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AMPH_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AMPH_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AMPH_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYN1_RAT	Dnm1	physical	9694653
AP2A1_HUMAN	AP2A1	physical	9259551
DYN1_HUMAN	DNM1	physical	9259551
SYNJ1_RAT	Synj1	physical	9195986
DYN1_RAT	Dnm1	physical	9195986
CLH1_RAT	Cltc	physical	11382783
CLCA_RAT	Clta	physical	11382783
AMPH_RAT	Amph	physical	11382783
AP2B1_RAT	Ap2b1	physical	11382783
EPN1_RAT	Epn1	physical	11382783
NECP1_RAT	Necap1	physical	17762867
CLH1_RAT	Cltc	physical	17762867

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.