dbPTM

NECP1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NECP1_RAT
UniProt AC	P69682
Protein Name	Adaptin ear-binding coat-associated protein 1
Gene Name	Necap1
Organism	Rattus norvegicus (Rat).
Sequence Length	277
Subcellular Localization	Cytoplasmic vesicle, clathrin-coated vesicle membrane . Cell membrane . Partially colocalizes with AP-2 at the plasma membrane.
Protein Description	Involved in endocytosis..
Protein Sequence	MAAELEYESVLCVKPDVSVYRIPPRASNRGYRASDWKLDQPDWTGRLRITSKGKIAYIKLEDKVSGELFAQAPVEQYPGIAVETVADSSRYFVIRIQDGTGRSAFIGIGFTDRGDAFDFNVSLQDHFKWVKQETEISKESQEMDSRPKLDLGFKEGQTIKLSIGNITAKKGGTSKPRASGTGGLSLLPPPPGGKVTIPPPSSSVAISNHVTPPPIPKSNHGSNDSDILLDLDSPAPVPTSAPAPAPASTSNDLWGDFSTASSSVPNQAPQPSNWVQF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Acetylation	GYRASDWKLDQPDWT CCCCCCCCCCCCCCC	47.37	22902405
59	Ubiquitination	KGKIAYIKLEDKVSG CCEEEEEEEECCCCC	32.90	-
201	Phosphorylation	KVTIPPPSSSVAISN CEECCCCCCCEEEEC	40.81	30181290
202	Phosphorylation	VTIPPPSSSVAISNH EECCCCCCCEEEECC	34.31	25575281
203	Phosphorylation	TIPPPSSSVAISNHV ECCCCCCCEEEECCC	21.65	23984901
207	Phosphorylation	PSSSVAISNHVTPPP CCCCEEEECCCCCCC	15.90	27097102
211	Phosphorylation	VAISNHVTPPPIPKS EEEECCCCCCCCCCC	23.64	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NECP1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NECP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NECP1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMPH_RAT	Amph	physical	17762867
BIN1_RAT	Bin1	physical	17762867
AP180_RAT	Snap91	physical	17762867
SYNJ1_RAT	Synj1	physical	17762867

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NECP1_RAT

Related Literatures of Post-Translational Modification