BIN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BIN1_RAT
• UniProt AC: O08839
• Protein Name: Myc box-dependent-interacting protein 1
• Gene Name: Bin1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 588
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation..
• Protein Sequence: MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLSECLQEVYEPEWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVSLEKQHGSNTFTVKAQPSDSAPEKGNKSPSPPPDGSPAATPEIRVNHEPEPASGASPGATIPKSPSQLRKGPPVPPPPKHTPSKEMKQEQILSLFDDAFVPEISVTTPSQFEAPGPFSEQASLLDLDFEPLPPVASPVKAPTPSGQSIPWDLWEPTESQAGVLPSGEPSSAEGSFAVAWPSQTAEPGPAQPAEASEVVGGTQEPGETAASEATSSSLPAVVVETFSATVNGAVEGSTTTGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEMGSKGV ------CCCCCCCCC	18.58	-
7	Ubiquitination	-MAEMGSKGVTAGKI -CCCCCCCCCCHHHH	52.23	-
146	Acetylation	RIAKRGRKLVDYDSA HHHHHCCCCCCHHHH	56.54	22902405
159	Phosphorylation	SARHHYESLQTAKKK HHHHHHHHHHHHCHH	20.72	22817900
162	Phosphorylation	HHYESLQTAKKKDEA HHHHHHHHHCHHCHH	45.82	23984901
164	Ubiquitination	YESLQTAKKKDEAKI HHHHHHHCHHCHHHC	64.84	-
189	Acetylation	APQWCQGKLQAHLVA CCHHHHHHHHHHHHH	16.14	22902405
258	Acetylation	NFHKEMSKLNQNLND HHHHHHHHHHHHHHH	50.58	22902405
276	Phosphorylation	SLEKQHGSNTFTVKA HHHHHCCCCEEEEEE	30.49	25403869
282	Ubiquitination	GSNTFTVKAQPSDSA CCCEEEEEEECCCCC	37.94	-
286	Phosphorylation	FTVKAQPSDSAPEKG EEEEEECCCCCCCCC	31.92	25403869
288	Phosphorylation	VKAQPSDSAPEKGNK EEEECCCCCCCCCCC	50.49	25403869
296	Phosphorylation	APEKGNKSPSPPPDG CCCCCCCCCCCCCCC	34.31	23712012
298	Phosphorylation	EKGNKSPSPPPDGSP CCCCCCCCCCCCCCC	58.07	23712012
304	Phosphorylation	PSPPPDGSPAATPEI CCCCCCCCCCCCCCE	20.81	23712012
308	Phosphorylation	PDGSPAATPEIRVNH CCCCCCCCCCEEECC	24.46	27097102
321	Phosphorylation	NHEPEPASGASPGAT CCCCCCCCCCCCCCC	45.68	29779826
324	Phosphorylation	PEPASGASPGATIPK CCCCCCCCCCCCCCC	27.65	23712012
328	Phosphorylation	SGASPGATIPKSPSQ CCCCCCCCCCCCHHH	43.67	27097102
332	Phosphorylation	PGATIPKSPSQLRKG CCCCCCCCHHHHCCC	25.16	27097102
334	Phosphorylation	ATIPKSPSQLRKGPP CCCCCCHHHHCCCCC	49.27	27097102
349	Phosphorylation	VPPPPKHTPSKEMKQ CCCCCCCCCCHHHCH	35.07	30411139
351	Phosphorylation	PPPKHTPSKEMKQEQ CCCCCCCCHHHCHHH	42.26	25403869
494	Phosphorylation	AVVVETFSATVNGAV EEEEEEEEEEECCEE	30.37	23712012

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BIN1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BIN1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BIN1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYNJ1_RAT	Synj1	physical	9195986
DYN1_RAT	Dnm1	physical	9195986
CLH1_RAT	Cltc	physical	11382783
CLCA_RAT	Clta	physical	11382783
AP2B1_RAT	Ap2b1	physical	11382783
AMPH_RAT	Amph	physical	15126636
DYN1_RAT	Dnm1	physical	15126636
NECP1_RAT	Necap1	physical	17762867

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.