YIPF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YIPF2_HUMAN
• UniProt AC: Q9BWQ6
• Protein Name: Protein YIPF2
• Gene Name: YIPF2
• Organism: Homo sapiens (Human).
• Sequence Length: 316
• Subcellular Localization: Golgi apparatus, cis-Golgi network membrane ; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane . Late endosome membrane . Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-G
• Protein Sequence: MASADELTFHEFEEATNLLADTPDAATTSRSDQLTPQGHVAVAVGSGGSYGAEDEVEEESDKAALLQEQQQQQQPGFWTFSYYQSFFDVDTSQVLDRIKGSLLPRPGHNFVRHHLRNRPDLYGPFWICATLAFVLAVTGNLTLVLAQRRDPSIHYSPQFHKVTVAGISIYCYAWLVPLALWGFLRWRKGVQERMGPYTFLETVCIYGYSLFVFIPMVVLWLIPVPWLQWLFGALALGLSAAGLVFTLWPVVREDTRLVATVLLSVVVLLHALLAMGCKLYFFQSLPPENVAPPPQITSLPSNIALSPTLPQSLAPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASADELTF ------CCCHHCCCH	17.27	22814378
3	Phosphorylation	-----MASADELTFH -----CCCHHCCCHH	34.65	29507054
8	Phosphorylation	MASADELTFHEFEEA CCCHHCCCHHHHHHH	22.39	28450419
16	Phosphorylation	FHEFEEATNLLADTP HHHHHHHHHHCCCCC	29.67	28450419
22	Phosphorylation	ATNLLADTPDAATTS HHHHCCCCCCCCCCC	19.91	25159151
27	Phosphorylation	ADTPDAATTSRSDQL CCCCCCCCCCCCCCC	27.33	27732954
28	Phosphorylation	DTPDAATTSRSDQLT CCCCCCCCCCCCCCC	19.88	27732954
29	Phosphorylation	TPDAATTSRSDQLTP CCCCCCCCCCCCCCC	25.98	27732954
35	Phosphorylation	TSRSDQLTPQGHVAV CCCCCCCCCCCEEEE	14.13	25159151
46	Phosphorylation	HVAVAVGSGGSYGAE EEEEEECCCCCCCCC	33.12	25159151
49	Phosphorylation	VAVGSGGSYGAEDEV EEECCCCCCCCCHHC	24.74	25884760
50	Phosphorylation	AVGSGGSYGAEDEVE EECCCCCCCCCHHCH	24.51	27251275
60	Phosphorylation	EDEVEEESDKAALLQ CHHCHHHHHHHHHHH	47.92	25159151
99	Ubiquitination	SQVLDRIKGSLLPRP HHHHHHHCCCCCCCC	43.26	-
255	Phosphorylation	WPVVREDTRLVATVL HHHHCCCHHHHHHHH	22.58	-
260	Phosphorylation	EDTRLVATVLLSVVV CCHHHHHHHHHHHHH	12.28	-
280	Phosphorylation	LAMGCKLYFFQSLPP HHCCCCHHHHCCCCH	6.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YIPF2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YIPF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YIPF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YIPF6_HUMAN	YIPF6	physical	16189514
RN185_HUMAN	RNF185	physical	25416956
YIPF6_HUMAN	YIPF6	physical	25416956
ACTA_HUMAN	ACTA2	physical	26186194
APOB_HUMAN	APOB	physical	26186194
FATE1_HUMAN	FATE1	physical	21516116
ACTA_HUMAN	ACTA2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.