UN5CL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UN5CL_HUMAN
• UniProt AC: Q8IV45
• Protein Name: UNC5C-like protein
• Gene Name: UNC5CL
• Organism: Homo sapiens (Human).
• Sequence Length: 518
• Subcellular Localization: Membrane ; Single-pass type III membrane protein . Cytoplasm .
• Protein Description: Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets..
• Protein Sequence: MCPQESSFQPSQFLLLVGVPVASVLLLAQCLRWHCPRRLLGACWTLNGQEEPVSQPTPQLENEVSRQHLPATLPEMVAFYQELHTPTQGQTMVRQLMHKLLVFSAREVDHRGGCLMLQDTGISLLIPPGAVAVGRQERVSLILVWDLSDAPSLSQAQGLVSPVVACGPHGASFLKPCTLTFKHCAEQPSHARTYSSNTTLLDAKVWRPLGRPGAHASRDECRIHLSHFSLYTCVLEAPVGREARKWLQLAVFCSPLVPGQSHLQLRIYFLNNTPCALQWALTNEQPHGGRLRGPCQLFDFNGARGDQCLKLTYISEGWENVDDSSCQLVPHLHIWHGKCPFRSFCFRRKAADENEDCSALTNEIIVTMHTFQDGLETKYMEILRFQASEEESWAAPPPVSQPPPCNRLPPELFEQLRMLLEPNSITGNDWRRLASHLGLCGMKIRFLSCQRSPAAAILELFEEQNGSLQELHYLMTVMERLDCASAIQNYLSGTHGGSPGPERGGARDNQGLELDEKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
85	Phosphorylation	AFYQELHTPTQGQTM HHHHHHCCCCCCHHH	40.43	27251275
87	Phosphorylation	YQELHTPTQGQTMVR HHHHCCCCCCHHHHH	46.62	27251275
91	Phosphorylation	HTPTQGQTMVRQLMH CCCCCCHHHHHHHHH	25.18	27251275
172	Phosphorylation	ACGPHGASFLKPCTL ECCCCCHHCCCCCEE	35.39	24961811
485	Phosphorylation	MERLDCASAIQNYLS HHHHHHHHHHHHHHC	32.03	23532336
490	Phosphorylation	CASAIQNYLSGTHGG HHHHHHHHHCCCCCC	5.95	23532336
492	Phosphorylation	SAIQNYLSGTHGGSP HHHHHHHCCCCCCCC	31.14	28857561
494	Phosphorylation	IQNYLSGTHGGSPGP HHHHHCCCCCCCCCC	17.61	28857561
498	Phosphorylation	LSGTHGGSPGPERGG HCCCCCCCCCCCCCC	31.13	26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UN5CL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UN5CL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UN5CL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NFKB1_HUMAN	NFKB1	physical	14769797
TF65_HUMAN	RELA	physical	14769797
BICD2_HUMAN	BICD2	physical	28514442
INSR_HUMAN	INSR	physical	28514442
NUMB_HUMAN	NUMB	physical	28514442
LRC41_HUMAN	LRRC41	physical	28514442
KDM8_HUMAN	KDM8	physical	28514442
IGF1R_HUMAN	IGF1R	physical	28514442
NUMBL_HUMAN	NUMBL	physical	28514442
FLVC1_HUMAN	FLVCR1	physical	28514442
CHRD1_HUMAN	CHORDC1	physical	28514442
UBP22_HUMAN	USP22	physical	28514442
DDRGK_HUMAN	DDRGK1	physical	28514442
CHK1_HUMAN	CHEK1	physical	28514442
P121A_HUMAN	POM121	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.