UBP38_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP38_HUMAN
• UniProt AC: Q8NB14
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 38
• Gene Name: USP38
• Organism: Homo sapiens (Human).
• Sequence Length: 1042
• Protein Description: Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked ubiquitin chains..
• Protein Sequence: MDKILEGLVSSSHPLPLKRVIVRKVVESAEHWLDEAQCEAMFDLTTRLILEGQDPFQRQVGHQVLEAYARYHRPEFESFFNKTFVLGLLHQGYHSLDRKDVAILDYIHNGLKLIMSCPSVLDLFSLLQVEVLRMVCERPEPQLCARLSDLLTDFVQCIPKGKLSITFCQQLVRTIGHFQCVSTQERELREYVSQVTKVSNLLQNIWKAEPATLLPSLQEVFASISSTDASFEPSVALASLVQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMIDWLSWPLAQHVDTWVIALLKGLAAVQKFTILIDVTLLKIELVFNRLWFPLVRPGALAVLSHMLLSFQHSPEAFHLIVPHVVNLVHSFKNDGLPSSTAFLVQLTELIHCMMYHYSGFPDLYEPILEAIKDFPKPSEEKIKLILNQSAWTSQSNSLASCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNGCNSLMKKLQHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVYNPTTAAFICDSLVNEKTIGSPPNEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQSHLLGRDSPSAVFEQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKDTAYVLLYKKQHSTNGLSGNNPTSGLWINGDPPLQKELMDAITKDNKLYLQEQELNARARALQAASASCSFRPNGFDDNDPPGSCGPTGGGGGGGFNTVGRLVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Ubiquitination	VQCIPKGKLSITFCQ HHHCCCCCCHHHHHH	45.23	-
182	Phosphorylation	IGHFQCVSTQERELR HCCCCCCCHHHHHHH	31.81	26699800
183	Phosphorylation	GHFQCVSTQERELRE CCCCCCCHHHHHHHH	17.66	26699800
439	Ubiquitination	CLSRLSGKSETGKTG HHHHHCCCCCCCCCC	41.57	-
486	Ubiquitination	NGCNSLMKKLQHLFA CCHHHHHHHHHHHHH	56.47	-
503	Phosphorylation	AHTQREAYAPRIFFE HHHCHHHHHCCEEEE	16.64	24719451
512	Phosphorylation	PRIFFEASRPPWFTP CCEEEECCCCCCCCC	37.82	24719451
535	Methylation	YLRFLLDRLHEEEKI HHHHHHHHHHHHHHH	37.60	115919625
541	Ubiquitination	DRLHEEEKILKVQAS HHHHHHHHHHHHHCC	57.53	-
541	Ubiquitination	DRLHEEEKILKVQAS HHHHHHHHHHHHHCC	57.53	-
584	Phosphorylation	RTSDGEKTLIEKMFG CCCCCCCHHHHHHHC	28.76	28060719
588	Ubiquitination	GEKTLIEKMFGGKLR CCCHHHHHHHCCCCH	32.32	-
588	Ubiquitination	GEKTLIEKMFGGKLR CCCHHHHHHHCCCCH	32.32	-
677	Phosphorylation	DSLVNEKTIGSPPNE HHHCCCCCCCCCCCC	25.13	26074081
680	Phosphorylation	VNEKTIGSPPNEFYC CCCCCCCCCCCCCCC	33.08	25849741
686	Phosphorylation	GSPPNEFYCSENTSV CCCCCCCCCCCCCCC	6.73	26074081
773	Ubiquitination	LRFSYDQKYHVRRKI HHCCCCCCHHHHCHH	34.13	21890473
773	Ubiquitination	LRFSYDQKYHVRRKI HHCCCCCCHHHHCHH	34.13	21890473
779	Ubiquitination	QKYHVRRKILDNVSL CCHHHHCHHHHCCCC	36.74	-
779	Ubiquitination	QKYHVRRKILDNVSL CCHHHHCHHHHCCCC	36.74	-
785	Phosphorylation	RKILDNVSLPLVLEL CHHHHCCCCCEEEEC	30.44	-
795	Ubiquitination	LVLELPVKRITSFSS EEEECCHHEECCCHH	35.82	-
795	Ubiquitination	LVLELPVKRITSFSS EEEECCHHEECCCHH	35.82	-
823	Ubiquitination	LSENLAKKLKPSGTD CCHHHHHHCCCCCCC	57.02	-
825	Ubiquitination	ENLAKKLKPSGTDEA HHHHHHCCCCCCCHH	46.12	-
825	Ubiquitination	ENLAKKLKPSGTDEA HHHHHHCCCCCCCHH	46.12	-
849	Phosphorylation	LSSVVVHSGISSESG HHHEEEECCCCCCCC	26.64	22468782
852	Phosphorylation	VVVHSGISSESGHYY EEEECCCCCCCCCCE	31.42	22468782
861	Phosphorylation	ESGHYYSYARNITST CCCCCEEEEEECCCC	8.08	22468782
895	Phosphorylation	SHLLGRDSPSAVFEQ HHHCCCCCHHHHHHH	21.28	26074081
897	Phosphorylation	LLGRDSPSAVFEQDL HCCCCCHHHHHHHHH	40.80	26074081
907	Ubiquitination	FEQDLENKEMSKEWF HHHHHCCCCCCCEEE	45.48	-
907	Ubiquitination	FEQDLENKEMSKEWF HHHHHCCCCCCCEEE	45.48	2190698
922	Phosphorylation	LFNDSRVTFTSFQSV ECCCCCCEEEEHHHH	21.78	24043423
924	Phosphorylation	NDSRVTFTSFQSVQK CCCCCEEEEHHHHHH	21.18	24043423
925	Phosphorylation	DSRVTFTSFQSVQKI CCCCEEEEHHHHHHH	19.66	24043423
928	Phosphorylation	VTFTSFQSVQKITSR CEEEEHHHHHHHHHC	25.22	24043423
931	Acetylation	TSFQSVQKITSRFPK EEHHHHHHHHHCCCC	45.88	30593291
982	Ubiquitination	ELMDAITKDNKLYLQ HHHHHHHHCCCHHHH	53.87	-
982	Ubiquitination	ELMDAITKDNKLYLQ HHHHHHHHCCCHHHH	53.87	-
985	Ubiquitination	DAITKDNKLYLQEQE HHHHHCCCHHHHHHH	48.95	-
1006	Phosphorylation	ALQAASASCSFRPNG HHHHHHHHCCCCCCC	14.06	22210691
1022	Phosphorylation	DDNDPPGSCGPTGGG CCCCCCCCCCCCCCC	22.98	22210691
1036	Phosphorylation	GGGGGFNTVGRLVF- CCCCCCCCCCCCCC-	23.29	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP38_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP38_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP38_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSPB1_HUMAN	HSPB1	physical	19615732
LEG7_HUMAN	LGALS7	physical	19615732
RL7_HUMAN	RPL7	physical	19615732
RS12_HUMAN	RPS12	physical	19615732
HMX3_HUMAN	HMX3	physical	19615732
H13_HUMAN	HIST1H1D	physical	26186194
DSRAD_HUMAN	ADAR	physical	26186194
FETUA_HUMAN	AHSG	physical	26186194
GNB5_HUMAN	GNB5	physical	26186194
H13_HUMAN	HIST1H1D	physical	28514442
FETUA_HUMAN	AHSG	physical	28514442
DSRAD_HUMAN	ADAR	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.