| UniProt ID | HMX3_HUMAN | |
|---|---|---|
| UniProt AC | A6NHT5 | |
| Protein Name | Homeobox protein HMX3 | |
| Gene Name | HMX3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 357 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity).. | |
| Protein Sequence | MPEPGPDAAGTASAQPQPPPPPPPAPKESPFSIKNLLNGDHHRPPPKPQPPPRTLFAPASAAAAAAAAAAAAAKGALEGAAGFALSQVGDLAFPRFEIPAQRFALPAHYLERSPAWWYPYTLTPAGGHLPRPEASEKALLRDSSPASGTDRDSPEPLLKADPDHKELDSKSPDEIILEESDSEESKKEGEAAPGAAGASVGAAAATPGAEDWKKGAESPEKKPACRKKKTRTVFSRSQVFQLESTFDMKRYLSSSERAGLAASLHLTETQVKIWFQNRRNKWKRQLAAELEAANLSHAAAQRIVRVPILYHENSAAEGAAAAAAGAPVPVSQPLLTFPHPVYYSHPVVSSVPLLRPV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 32 | Phosphorylation | APKESPFSIKNLLNG CCCCCCCCHHHCCCC | 35.72 | - | |
| 102 | Methylation | RFEIPAQRFALPAHY CCCCCHHHCCCCHHH | 22.40 | 115383249 | |
| 121 | Phosphorylation | PAWWYPYTLTPAGGH CCCCCCEEECCCCCC | 21.46 | 25921289 | |
| 135 | Phosphorylation | HLPRPEASEKALLRD CCCCCCHHHHHHHCC | 37.66 | 25921289 | |
| 143 | Phosphorylation | EKALLRDSSPASGTD HHHHHCCCCCCCCCC | 31.61 | 22167270 | |
| 144 | Phosphorylation | KALLRDSSPASGTDR HHHHCCCCCCCCCCC | 28.86 | 22167270 | |
| 147 | Phosphorylation | LRDSSPASGTDRDSP HCCCCCCCCCCCCCC | 45.68 | 22167270 | |
| 149 | Phosphorylation | DSSPASGTDRDSPEP CCCCCCCCCCCCCCC | 25.93 | 22167270 | |
| 153 | Phosphorylation | ASGTDRDSPEPLLKA CCCCCCCCCCCCHHC | 31.86 | 22167270 | |
| 169 | Phosphorylation | PDHKELDSKSPDEII CCCCCCCCCCCCCEE | 47.89 | 29449344 | |
| 171 | Phosphorylation | HKELDSKSPDEIILE CCCCCCCCCCCEEEE | 41.35 | 30576142 | |
| 180 | Phosphorylation | DEIILEESDSEESKK CCEEEECCCCHHHHH | 36.74 | 30576142 | |
| 182 | Phosphorylation | IILEESDSEESKKEG EEEECCCCHHHHHHH | 53.17 | 30108239 | |
| 185 | Phosphorylation | EESDSEESKKEGEAA ECCCCHHHHHHHCCC | 45.00 | 23186163 | |
| 213 | Ubiquitination | TPGAEDWKKGAESPE CCCHHHHHCCCCCCC | 54.36 | 29967540 | |
| 218 | Phosphorylation | DWKKGAESPEKKPAC HHHCCCCCCCCCCCC | 37.51 | 26552605 | |
| 251 | Phosphorylation | STFDMKRYLSSSERA CCCCHHHHCCHHHHH | 12.86 | 29759185 | |
| 269 | Phosphorylation | ASLHLTETQVKIWFQ HHHCCHHHHHHHHHH | 33.17 | 29759185 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HMX3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HMX3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HMX3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HMX3_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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