TRXB3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRXB3_ARATH
• UniProt AC: O22229
• Protein Name: NADPH-dependent thioredoxin reductase 3
• Gene Name: NTRC
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 529
• Subcellular Localization: Plastid, chloroplast .
• Protein Description: Thioredoxin reductase (TR) that exhibits both TR and thioredoxin (Trx) activities. Contains a C-terminal functional Trx domain. Functions as an electron donor for plastidial 2-Cys peroxiredoxins and participates in a NADPH-dependent hydrogen peroxide scavenging system in chloroplasts in the dark. Required for chlorophyll biosynthesis and biogenesis of the photosynthetic apparatus. Activates aerobic cyclase which converts Mg-protoporhyrin monomethyl ester into protochlorophyllide. Involved in a light-dependent regulation of starch biosynthesis by redox activation of the ADP-glucose pyrophosphorylase (AGPase), a central enzyme of starch synthesis..
• Protein Sequence: MAASPKIGIGIASVSSPHRVSAASSALSPPPHLFFLTTTTTTRHGGSYLLRQPTRTRSSDSLRLRVSATANSPSSSSSGGEIIENVVIIGSGPAGYTAAIYAARANLKPVVFEGYQMGGVPGGQLMTTTEVENFPGFPDGITGPDLMEKMRKQAERWGAELYPEDVESLSVTTAPFTVQTSERKVKCHSIIYATGATARRLRLPREEEFWSRGISACAICDGASPLFKGQVLAVVGGGDTATEEALYLTKYARHVHLLVRRDQLRASKAMQDRVINNPNITVHYNTETVDVLSNTKGQMSGILLRRLDTGEETELEAKGLFYGIGHSPNSQLLEGQVELDSSGYVLVREGTSNTSVEGVFAAGDVQDHEWRQAVTAAGSGCIAALSAERYLTSNNLLVEFHQPQTEEAKKEFTQRDVQEKFDITLTKHKGQYALRKLYHESPRVILVLYTSPTCGPCRTLKPILNKVVDEYNHDVHFVEIDIEEDQEIAEAAGIMGTPCVQFFKNKEMLRTISGVKMKKEYREFIEANK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
508	Sulfoxidation	QFFKNKEMLRTISGV HHHCCHHHHHHHCCC	3.07	25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRXB3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRXB3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRXB3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRXB3_ARATH	NTRC	physical	21798944
CBSX2_ARATH	LEJ1	physical	21798944
M2K3_ARATH	MKK3	physical	21798944
Y4193_ARATH	AT4G10930	physical	21798944
TCP13_ARATH	PTF1	physical	21798944
EDR4_ARATH	AT5G05190	physical	21798944
TRXX_ARATH	THX	physical	25448674
BAS1A_ARATH	AT3G11630	physical	16884685

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.