EDR4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EDR4_ARATH
• UniProt AC: Q9FHK4
• Protein Name: Protein ENHANCED DISEASE RESISTANCE 4 {ECO:0000303|PubMed:25747881}
• Gene Name: EDR4 {ECO:0000303|PubMed:25747881}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 615
• Subcellular Localization: Cell membrane . Endosome . Displays dynamic movement in cells with accumulation at the plasma membrane around pathogenic fungus penetration site.
• Protein Description: Plays a negative role in salicylic acid (SA)-mediated resistance to powdery mildew (e.g. Golovinomyces cichoracearum). May modulate plant immunity by regulating the relocation of EDR1 by interacting with CHC2 and modulating endocytosis..
• Protein Sequence: MASQTGQKIRLVRCPKCLKILQEDEDVPVYQCGGCSAILQAKRRNIAPSSTPSAGETERAQANEPQSVPETNNVSSSSGQDTVLPSSPGRSVDQEYEKGRNASMESTEKELDDLELSNGDGTNEIQEQECSLGDSEKNEREDNSRLESHMMNTVAEAAGSGSSSGSLSVDHVVAARASNPSGNSEISPDASPVEEKQSQLDILANKTPSAYDVVAARASNSSGNAEISPDASPVEEKQSQLDYPANKTSSAYDGSESSSDEREGQLLDDDEQWNALQKIRSGKFEMHRYPGYKEQGASSSSPFSENRRNGITTYNERHQNRSLQLEGPGGRLGRQGRRHVTEQLRPDMPFYPRESYTRGSPSHPSHDEFDRYPRAHSLQMPSYAGGMNHDFVDYMYHNNPRARGQGQGSRISGEMGRNHGGWYSGQLHNSYSSYSASPQRPMEQPEYHPRWRREIVSDVEDHQRNRHAGHHHELQTRRLRERQRVAKRHVRPTAGGAPFVSCYSCSENLQLPVDFLIFKRKHHLLRCGTCTTVLRFSLQSRNHLVPAVTHDINANRNSNSTSESPIDKAPSKPEKLRSSVQDEELPVARGSPLHRLMGYSTVSQVFKVSQRPPSI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	QDTVLPSSPGRSVDQ CCCCCCCCCCCCHHH		30589143
181	Phosphorylation	AARASNPSGNSEISP EEECCCCCCCCCCCC		25561503
184	Phosphorylation	ASNPSGNSEISPDAS CCCCCCCCCCCCCCC		25561503
187	Phosphorylation	PSGNSEISPDASPVE CCCCCCCCCCCCCHH		25561503
191	Phosphorylation	SEISPDASPVEEKQS CCCCCCCCCHHHHHH		25561503
222	Phosphorylation	AARASNSSGNAEISP HHHCCCCCCCCCCCC		30407730
228	Phosphorylation	SSGNAEISPDASPVE CCCCCCCCCCCCCHH		30407730
232	Phosphorylation	AEISPDASPVEEKQS CCCCCCCCCHHHHHH		30407730
298	Phosphorylation	GYKEQGASSSSPFSE CCCCCCCCCCCCCCC		25561503
299	Phosphorylation	YKEQGASSSSPFSEN CCCCCCCCCCCCCCC		30407730
300	Phosphorylation	KEQGASSSSPFSENR CCCCCCCCCCCCCCC		25561503
301	Phosphorylation	EQGASSSSPFSENRR CCCCCCCCCCCCCCC		30407730
304	Phosphorylation	ASSSSPFSENRRNGI CCCCCCCCCCCCCCC		30407730
322	Phosphorylation	NERHQNRSLQLEGPG HHHHCCCCCEECCCC		30589143
360	Phosphorylation	RESYTRGSPSHPSHD CCCCCCCCCCCCCCC		30291188
362	Phosphorylation	SYTRGSPSHPSHDEF CCCCCCCCCCCCCCH		25561503
365	Phosphorylation	RGSPSHPSHDEFDRY CCCCCCCCCCCHHCC		25561503
457	Phosphorylation	RWRREIVSDVEDHQR HHHHHHHHHHHHHHH		30291188
578	Phosphorylation	SKPEKLRSSVQDEEL CCCHHHHHCCCCCCC		23111157
579	Phosphorylation	KPEKLRSSVQDEELP CCHHHHHCCCCCCCC		30407730
601	Phosphorylation	HRLMGYSTVSQVFKV HHHCCCCHHHHHHHH		24894044
603	Phosphorylation	LMGYSTVSQVFKVSQ HCCCCHHHHHHHHHC		30589143
609	Phosphorylation	VSQVFKVSQRPPSI- HHHHHHHHCCCCCC-		25561503
614	Phosphorylation	KVSQRPPSI------ HHHCCCCCC------		25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EDR4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EDR4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EDR4_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APRR1_ARATH	TOC1	physical	21798944

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.