| UniProt ID | TOLIP_RAT | |
|---|---|---|
| UniProt AC | A2RUW1 | |
| Protein Name | Toll-interacting protein | |
| Gene Name | Tollip {ECO:0000312|EMBL:AAI33068.1} | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 274 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).. | |
| Protein Sequence | MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGAVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MATTVSTQR ------CCCEECCCC | 16.39 | - | |
| 13 | Phosphorylation | STQRGPVYIGELPQD CCCCCCEEEECCCCC | 13.32 | - | |
| 66 | Ubiquitination | VVQAKLAKNYGMTRM HHHHHHHHHHCCCCC | 62.23 | - | |
| 96 | Ubiquitination | PTAHNGAKNPRWNKV CCCCCCCCCCCCCCE | 69.73 | - | |
| 143 | Ubiquitination | ITIPESLKQGQVEDE EECCHHHHCCCCCCE | 62.76 | - | |
| 235 | Ubiquitination | RCNEEDLKAIQDMFP CCCHHHHHHHHHHCC | 56.62 | - | |
| 266 | Phosphorylation | NKDAAINSLLQMGEE CHHHHHHHHHHHCCC | 25.09 | 28689409 | |
| 274 | Phosphorylation | LLQMGEES------- HHHHCCCC------- | 41.02 | 22673903 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TOLIP_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TOLIP_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TOLIP_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| UBC9_RAT | Ube2i | physical | 19198660 | |
| PIAS2_RAT | Pias2 | physical | 19198660 | |
| SUMO1_RAT | Sumo1 | physical | 19198660 | |
| TOLIP_RAT | Tollip | physical | 19198660 | |
| BEX1_RAT | Bex1 | physical | 19198660 | |
| RACK1_RAT | Gnb2l1 | physical | 19198660 | |
| UBC_RAT | Ubc | physical | 19198660 | |
| RS27_RAT | Rps27 | physical | 19198660 | |
| IL1AP_RAT | Il1rap | physical | 19198660 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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