IL1AP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL1AP_RAT
• UniProt AC: Q63621
• Protein Name: Interleukin-1 receptor accessory protein
• Gene Name: Il1rap
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 570
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity). Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity)..
• Protein Sequence: MGLPWCLMSLFFCGILQSHASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMRLPVHRLYIEQGIHNITCPNVDGYFPSSVKPSVTWYKGCTEIVNFHNVQPKGMNLSFFIPLVSNNGNYTCVVTYLENGRLFHLTRTMTVKVVGSPKDAVPPHIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSHNEIWWTIDGKKPDDVPVDITIIESVSYSSTEDETRTQILSIKKVTPEDLKRNYVCHARNAEGEAEQAAKVKQKVIPPRYTVELACGFGATVFLVVVLIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSFPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKDLKVKELKRAKSVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRWSSSDKQGLSYSSLKNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	N-linked_Glycosylation	FEHFLKYNYSTAHSS HHHHHHCCHHHHCCC	23.77	-
107	N-linked_Glycosylation	WFRPTLLNDTGNYTC EECCCCCCCCCCEEE	48.16	-
111	N-linked_Glycosylation	TLLNDTGNYTCMLRN CCCCCCCCEEEEEEC	30.91	-
118	N-linked_Glycosylation	NYTCMLRNTTYCSKV CEEEEEECCCCCCEE	32.58	-
157	N-linked_Glycosylation	YIEQGIHNITCPNVD HHHCCCEECCCCCCC	29.37	-
196	N-linked_Glycosylation	NVQPKGMNLSFFIPL CCCCCCCEEEEEEEE	41.00	-
209	N-linked_Glycosylation	PLVSNNGNYTCVVTY EEEECCCCEEEEEEE	30.94	-
555	Phosphorylation	VKKSPRWSSSDKQGL CCCCCCCCCCCCCCC	22.65	27097102
556	Phosphorylation	KKSPRWSSSDKQGLS CCCCCCCCCCCCCCC	35.28	27097102
557	Phosphorylation	KSPRWSSSDKQGLSY CCCCCCCCCCCCCCH	43.22	27097102
559	Ubiquitination	PRWSSSDKQGLSYSS CCCCCCCCCCCCHHH	48.49	-
563	Phosphorylation	SSDKQGLSYSSLKNV CCCCCCCCHHHCCCC	29.78	27097102
564	Phosphorylation	SDKQGLSYSSLKNV- CCCCCCCHHHCCCC-	13.81	27097102
565	Phosphorylation	DKQGLSYSSLKNV-- CCCCCCHHHCCCC--	26.31	28432305
566	Phosphorylation	KQGLSYSSLKNV--- CCCCCHHHCCCC---	34.82	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL1AP_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL1AP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL1AP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of IL1AP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.