BEX1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BEX1_RAT
• UniProt AC: Q3MKQ2
• Protein Name: Protein BEX1
• Gene Name: Bex1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 128
• Subcellular Localization: Nucleus. Cytoplasm. Shuttles between the cytoplasm and the nucleus. Predominantly nuclear.
• Protein Description: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states..
• Protein Sequence: MESKDQGAKNLNMENDHQKKEEKEEKPQDTIKREPVVAPTFEAGKNCAPRGGRRRFRVRQPIAHYRWDLMHRVGEPQGRMREENVQRFGEDMRQLMEKLRERQLSHSLRAVSTDPPHHDHHDEFCLMP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MESKDQGAKNL ----CCCHHHHHHCC	40.54	22902405
105	Phosphorylation	KLRERQLSHSLRAVS HHHHHHHHHHHHHHC	11.59	16498402
107	Phosphorylation	RERQLSHSLRAVSTD HHHHHHHHHHHHCCC	19.04	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
105	S	Phosphorylation	Kinase	AKT1	P31749	PSP
105	S	Phosphorylation	Kinase	AKT1	P47196	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
105	S	Phosphorylation	Phosphorylation of Ser-105 protects it from the proteasome.	16498402

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BEX1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of BEX1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Bex1, a novel interactor of the p75 neurotrophin receptor, linksneurotrophin signaling to the cell cycle.";
Vilar M., Murillo-Carretero M., Mira H., Magnusson K., Besset V.,Ibanez C.F.;
EMBO J. 25:1219-1230(2006).
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTALSTAGE, PHOSPHORYLATION AT SER-105, UBIQUITINATION, INTERACTION WITHNGFR, AND MUTAGENESIS OF 53-ARG--ARG-55 AND SER-105.
PubMed: 16498402