TMPS5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMPS5_HUMAN
• UniProt AC: Q9H3S3
• Protein Name: Transmembrane protease serine 5
• Gene Name: TMPRSS5
• Organism: Homo sapiens (Human).
• Sequence Length: 457
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein .
• Protein Description: May play a role in hearing..
• Protein Sequence: MSLMLDDQPPMEAQYAEEGPGPGIFRAEPGDQQHPISQAVCWRSMRRGCAVLGALGLLAGAGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSFRINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLMLDDQP ------CCCCCCCCC	23.61	29978859
15	Phosphorylation	QPPMEAQYAEEGPGP CCCCHHHCCCCCCCC	24.03	29978859
163	N-linked_Glycosylation	LTHHKGVNLTDIKLN CCCCCCCCCCEEECC	45.98	UniProtKB CARBOHYD
170	N-linked_Glycosylation	NLTDIKLNSSQEFAQ CCCEEECCCHHHHHH	34.31	UniProtKB CARBOHYD
195	N-linked_Glycosylation	EAWQPRNNCTSGQVV HHCCCCCCCCCCCEE	31.55	UniProtKB CARBOHYD
269	Phosphorylation	SFRLARLSSWRVHAG HHHHHHHHCCEEEEC	23.46	28674151
270	Phosphorylation	FRLARLSSWRVHAGL HHHHHHHCCEEEECC	24.40	23532336
279	Phosphorylation	RVHAGLVSHSAVRPH EEEECCCCCCCCCCC	19.43	26270265
281	Phosphorylation	HAGLVSHSAVRPHQG EECCCCCCCCCCCCC	22.43	26270265
319	N-linked_Glycosylation	LRLQTALNFSDTVGA HHHHHHHCCCCCCCC	31.73	UniProtKB CARBOHYD
375	N-linked_Glycosylation	LFSTQLCNSSCVYSG HCCCCCCCCCCCCCC	45.62	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMPS5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMPS5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMPS5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM214_HUMAN	TMEM214	physical	26186194
YBEY_HUMAN	YBEY	physical	26186194
TOR3A_HUMAN	TOR3A	physical	26186194
C42S2_HUMAN	CDC42SE2	physical	26186194
ARF5_HUMAN	ARF5	physical	26186194
BDH_HUMAN	BDH1	physical	26186194
N42L2_HUMAN	N4BP2L2	physical	26186194
N42L2_HUMAN	N4BP2L2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.