TLDC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLDC2_HUMAN
• UniProt AC: A0PJX2
• Protein Name: TLD domain-containing protein 2
• Gene Name: TLDC2
• Organism: Homo sapiens (Human).
• Sequence Length: 215
• Protein Sequence: MRGLRWRYTRLPSQVEDTLSGEEGNEEEEEEEAAPDPAAAPEDPTVPQLTEASQVLSASEIRQLSFHFPPRVTGHPWSLVFCTSRDGFSLQSLYRRMEGCSGPVLLVLRDQDGQIFGAFSSSAIRLSKGFYGTGETFLFSFSPQLKVFKWTGSNSFFVKGDLDSLMMGSGSGRFGLWLDGDLFRGGSSPCPTFNNEVLARQEQFCIQELEAWLLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
120	Phosphorylation	GQIFGAFSSSAIRLS CCEEEEECHHEEECC		28258704
121	Phosphorylation	QIFGAFSSSAIRLSK CEEEEECHHEEECCC		28258704
122	Phosphorylation	IFGAFSSSAIRLSKG EEEEECHHEEECCCC		28258704
153	Phosphorylation	KVFKWTGSNSFFVKG EEEEECCCCCEEEEC		21712546
155	Phosphorylation	FKWTGSNSFFVKGDL EEECCCCCEEEECCH		21712546
169	Phosphorylation	LDSLMMGSGSGRFGL HHHEECCCCCCCCEE		19053533

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLDC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLDC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLDC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATC1_HUMAN	ATP6V1C1	physical	28514442
VATD_HUMAN	ATP6V1D	physical	28514442
VATE1_HUMAN	ATP6V1E1	physical	28514442
VATB2_HUMAN	ATP6V1B2	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.