dbPTM

THAP8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	THAP8_HUMAN
UniProt AC	Q8NA92
Protein Name	THAP domain-containing protein 8
Gene Name	THAP8
Organism	Homo sapiens (Human).
Sequence Length	274
Subcellular Localization
Protein Description
Protein Sequence	MPKYCRAPNCSNTAGRLGADNRPVSFYKFPLKDGPRLQAWLQHMGCEHWVPSCHQHLCSEHFTPSCFQWRWGVRYLRPDAVPSIFSRGPPAKSQRRTRSTQKPVSPPPPLQKNTPLPQSPAIPVSGPVRLVVLGPTSGSPKTVATMLLTPLAPAPTPERSQPEVPAQQAQTGLGPVLGALQRRVRRLQRCQERHQAQLQALERLAQQLHGESLLARARRGLQRLTTAQTLGPEESQTFTIICGGPDIAMVLAQDPAPATVDAKPELLDTRIPSA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Ubiquitination	NRPVSFYKFPLKDGP CCCEEEEEEECCCCH	38.20	-
32	Ubiquitination	SFYKFPLKDGPRLQA EEEEEECCCCHHHHH	61.96	-
105	Phosphorylation	RSTQKPVSPPPPLQK CCCCCCCCCCCCCCC	39.97	-
139	Phosphorylation	VLGPTSGSPKTVATM EECCCCCCCHHHHHH	24.00	25627689

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of THAP8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of THAP8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of THAP8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYL1_HUMAN	DYNLL1	physical	16169070
P53_HUMAN	TP53	physical	16169070
SETB1_HUMAN	SETDB1	physical	16169070
TMED9_HUMAN	TMED9	physical	21988832
UB2D2_HUMAN	UBE2D2	physical	26186194
LASP1_HUMAN	LASP1	physical	26186194
ANM7_HUMAN	PRMT7	physical	26186194
CI016_HUMAN	C9orf16	physical	26186194
ANM7_HUMAN	PRMT7	physical	28514442
UB2D2_HUMAN	UBE2D2	physical	28514442
LASP1_HUMAN	LASP1	physical	28514442
CI016_HUMAN	C9orf16	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of THAP8_HUMAN

Related Literatures of Post-Translational Modification