dbPTM

TENS4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TENS4_HUMAN
UniProt AC	Q8IZW8
Protein Name	Tensin-4
Gene Name	TNS4
Organism	Homo sapiens (Human).
Sequence Length	715
Subcellular Localization	Cell junction, focal adhesion . Cytoplasm, cytoskeleton .
Protein Description	May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3..
Protein Sequence	MSQVMSSPLLAGGHAVSLAPCDEPRRTLHPAPSPSLPPQCSYYTTEGWGAQALMAPVPCMGPPGRLQQAPQVEAKATCFLPSPGEKALGTPEDLDSYIDFSLESLNQMILELDPTFQLLPPGTGGSQAELAQSTMSMRKKEESEALDIKYIEVTSARSRCHDGPQHCSSPSVTPPFGSLRSGGLLLSRDVPRETRSSSESLIFSGNQGRGHQRPLPPSEGLSPRPPNSPSISIPCMGSKASSPHGLGSPLVASPRLEKRLGGLAPQRGSRISVLSASPVSDVSYMFGSSQSLLHSSNSSHQSSSRSLESPANSSSSLHSLGSVSLCTRPSDFQAPRNPTLTMGQPRTPHSPPLAKEHASSCPPSITNSMVDIPIVLINGCPEPGSSPPQRTPGHQNSVQPGAASPSNPCPATRSNSQTLSDAPFTTCPEGPARDMQPTMKFVMDTSKYWFKPNITREQAIELLRKEEPGAFVIRDSSSYRGSFGLALKVQEVPASAQSRPGEDSNDLIRHFLIESSAKGVHLKGADEEPYFGSLSAFVCQHSIMALALPCKLTIPQRELGGADGASDSTDSPASCQKKSAGCHTLYLSSVSVETLTGALAVQKAISTTFERDILPTPTVVHFKVTEQGITLTDVQRKVFFRRHYPLTTLRFCGMDPEQRKWQKYCKPSWIFGFVAKSQTEPQENVCHLFAEYDMVQPASQVIGLVTALLQDAERM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSQVMSSPLLAGG --CCCCCCCCCCCCC	29.92	24719451
7	Phosphorylation	-MSQVMSSPLLAGGH -CCCCCCCCCCCCCE	11.06	23090842
17	Phosphorylation	LAGGHAVSLAPCDEP CCCCEEEEECCCCCC	21.43	23090842
42	Phosphorylation	SLPPQCSYYTTEGWG CCCCCCCEEECCCCC	16.68	-
75	Ubiquitination	QAPQVEAKATCFLPS CCCCEEEECEEECCC	30.62	-
82	Phosphorylation	KATCFLPSPGEKALG ECEEECCCCCHHHCC	47.92	21712546
97	Phosphorylation	TPEDLDSYIDFSLES CCHHHHHHHCCCHHH	12.27	20736484
115	Phosphorylation	MILELDPTFQLLPPG HHHHCCCCEECCCCC	24.55	20068231
123	Phosphorylation	FQLLPPGTGGSQAEL EECCCCCCCCCHHHH	44.11	20068231
126	Phosphorylation	LPPGTGGSQAELAQS CCCCCCCCHHHHHHH	27.80	20068231
133	Phosphorylation	SQAELAQSTMSMRKK CHHHHHHHHHHHHHH	22.07	20068231
134	Phosphorylation	QAELAQSTMSMRKKE HHHHHHHHHHHHHHH	10.94	20068231
136	Phosphorylation	ELAQSTMSMRKKEES HHHHHHHHHHHHHHH	18.61	20068231
139	Ubiquitination	QSTMSMRKKEESEAL HHHHHHHHHHHHHHC	56.76	-
140	Ubiquitination	STMSMRKKEESEALD HHHHHHHHHHHHHCC	57.24	21906983
150	Phosphorylation	SEALDIKYIEVTSAR HHHCCCEEEEEECCC	11.57	19534553
168	Phosphorylation	HDGPQHCSSPSVTPP CCCCCCCCCCCCCCC	43.06	23090842
169	Phosphorylation	DGPQHCSSPSVTPPF CCCCCCCCCCCCCCC	26.96	29496963
171	Phosphorylation	PQHCSSPSVTPPFGS CCCCCCCCCCCCCCC	40.34	23090842
173	Phosphorylation	HCSSPSVTPPFGSLR CCCCCCCCCCCCCCC	29.58	29496963
181	Phosphorylation	PPFGSLRSGGLLLSR CCCCCCCCCCEEEEC	42.37	28674419
194	Phosphorylation	SRDVPRETRSSSESL ECCCCCCCCCCCCEE	36.81	23927012
196	Phosphorylation	DVPRETRSSSESLIF CCCCCCCCCCCEEEE	45.71	29496963
197	Phosphorylation	VPRETRSSSESLIFS CCCCCCCCCCEEEEE	34.53	29496963
198	Phosphorylation	PRETRSSSESLIFSG CCCCCCCCCEEEEEC	32.24	29496963
200	Phosphorylation	ETRSSSESLIFSGNQ CCCCCCCEEEEECCC	28.81	23927012
204	Phosphorylation	SSESLIFSGNQGRGH CCCEEEEECCCCCCC	29.82	23927012
222	Phosphorylation	LPPSEGLSPRPPNSP CCCCCCCCCCCCCCC	29.71	24719451
228	Phosphorylation	LSPRPPNSPSISIPC CCCCCCCCCCEEECC	26.29	-
230	Phosphorylation	PRPPNSPSISIPCMG CCCCCCCCEEECCCC	28.87	-
232	Phosphorylation	PPNSPSISIPCMGSK CCCCCCEEECCCCCC	25.47	-
241	Phosphorylation	PCMGSKASSPHGLGS CCCCCCCCCCCCCCC	48.41	23927012
242	Phosphorylation	CMGSKASSPHGLGSP CCCCCCCCCCCCCCC	26.27	23927012
248	Phosphorylation	SSPHGLGSPLVASPR CCCCCCCCCCCCCHH	21.80	23927012
253	Phosphorylation	LGSPLVASPRLEKRL CCCCCCCCHHHHHHH	11.76	23927012
269	Phosphorylation	GLAPQRGSRISVLSA CCCCCCCCCEEEEEC	28.73	24719451
272	Phosphorylation	PQRGSRISVLSASPV CCCCCCEEEEECCCC	18.85	23090842
275	Phosphorylation	GSRISVLSASPVSDV CCCEEEEECCCCCCC	25.25	23090842
277	Phosphorylation	RISVLSASPVSDVSY CEEEEECCCCCCCHH	23.58	23090842
280	Phosphorylation	VLSASPVSDVSYMFG EEECCCCCCCHHHHC	35.36	23090842
283	Phosphorylation	ASPVSDVSYMFGSSQ CCCCCCCHHHHCCCH	18.83	23090842
284	Phosphorylation	SPVSDVSYMFGSSQS CCCCCCHHHHCCCHH	9.05	19534553
288	Phosphorylation	DVSYMFGSSQSLLHS CCHHHHCCCHHHHHC	17.59	23090842
289	Phosphorylation	VSYMFGSSQSLLHSS CHHHHCCCHHHHHCC	24.94	23090842
291	Phosphorylation	YMFGSSQSLLHSSNS HHHCCCHHHHHCCCC	34.54	23090842
295	Phosphorylation	SSQSLLHSSNSSHQS CCHHHHHCCCCCCCC	31.05	23090842
296	Phosphorylation	SQSLLHSSNSSHQSS CHHHHHCCCCCCCCC	29.95	23090842
298	Phosphorylation	SLLHSSNSSHQSSSR HHHHCCCCCCCCCCC	31.01	23090842
299	Phosphorylation	LLHSSNSSHQSSSRS HHHCCCCCCCCCCCC	29.78	23090842
302	Phosphorylation	SSNSSHQSSSRSLES CCCCCCCCCCCCCCC	25.51	23090842
303	Phosphorylation	SNSSHQSSSRSLESP CCCCCCCCCCCCCCC	24.17	23090842
304	Phosphorylation	NSSHQSSSRSLESPA CCCCCCCCCCCCCCC	31.00	23090842
306	Phosphorylation	SHQSSSRSLESPANS CCCCCCCCCCCCCCC	38.14	23090842
309	Phosphorylation	SSSRSLESPANSSSS CCCCCCCCCCCCCCC	34.31	27251275
313	Phosphorylation	SLESPANSSSSLHSL CCCCCCCCCCCCCCC	33.43	23090842
314	Phosphorylation	LESPANSSSSLHSLG CCCCCCCCCCCCCCC	24.61	23090842
315	Phosphorylation	ESPANSSSSLHSLGS CCCCCCCCCCCCCCC	36.42	23090842
316	Phosphorylation	SPANSSSSLHSLGSV CCCCCCCCCCCCCCE	31.86	23090842
319	Phosphorylation	NSSSSLHSLGSVSLC CCCCCCCCCCCEEEC	39.45	23090842
322	Phosphorylation	SSLHSLGSVSLCTRP CCCCCCCCEEECCCC	17.52	23090842
324	Phosphorylation	LHSLGSVSLCTRPSD CCCCCCEEECCCCHH	21.30	23090842
327	Phosphorylation	LGSVSLCTRPSDFQA CCCEEECCCCHHCCC	51.40	23090842
330	Phosphorylation	VSLCTRPSDFQAPRN EEECCCCHHCCCCCC	48.00	23090842
341	Phosphorylation	APRNPTLTMGQPRTP CCCCCCCCCCCCCCC	23.02	23090842
347	Phosphorylation	LTMGQPRTPHSPPLA CCCCCCCCCCCCCCH	31.85	23927012
350	Phosphorylation	GQPRTPHSPPLAKEH CCCCCCCCCCCHHHH	29.44	28355574
359	Phosphorylation	PLAKEHASSCPPSIT CCHHHHHHCCCCCCC	34.09	25247763
360	Phosphorylation	LAKEHASSCPPSITN CHHHHHHCCCCCCCC	31.27	25247763
364	Phosphorylation	HASSCPPSITNSMVD HHHCCCCCCCCCCCC	27.47	25247763
366	Phosphorylation	SSCPPSITNSMVDIP HCCCCCCCCCCCCCE	26.11	25247763
368	Phosphorylation	CPPSITNSMVDIPIV CCCCCCCCCCCCEEE	16.13	25247763
385	Phosphorylation	NGCPEPGSSPPQRTP CCCCCCCCCCCCCCC	50.84	23663014
386	Phosphorylation	GCPEPGSSPPQRTPG CCCCCCCCCCCCCCC	46.65	23663014
391	Phosphorylation	GSSPPQRTPGHQNSV CCCCCCCCCCCCCCC	28.51	28674419
404	Phosphorylation	SVQPGAASPSNPCPA CCCCCCCCCCCCCCC	28.47	21712546
412	O-linked_Glycosylation	PSNPCPATRSNSQTL CCCCCCCCCCCCCCC	21.55	31492838
414	Phosphorylation	NPCPATRSNSQTLSD CCCCCCCCCCCCCCC	36.16	23927012
416	Phosphorylation	CPATRSNSQTLSDAP CCCCCCCCCCCCCCC	26.28	23927012
418	Phosphorylation	ATRSNSQTLSDAPFT CCCCCCCCCCCCCCC	28.22	25394399
420	Phosphorylation	RSNSQTLSDAPFTTC CCCCCCCCCCCCCCC	34.80	23927012
438	Phosphorylation	PARDMQPTMKFVMDT CCCCCCCCEEEEECC	18.99	25954137
440	Ubiquitination	RDMQPTMKFVMDTSK CCCCCCEEEEECCCC	36.97	-
446	Phosphorylation	MKFVMDTSKYWFKPN EEEEECCCCCCCCCC	21.34	25954137
448	Phosphorylation	FVMDTSKYWFKPNIT EEECCCCCCCCCCCC	18.82	-
451	Ubiquitination	DTSKYWFKPNITREQ CCCCCCCCCCCCHHH	24.02	-
465	Ubiquitination	QAIELLRKEEPGAFV HHHHHHHCCCCCCEE	67.41	-
476	Phosphorylation	GAFVIRDSSSYRGSF CCEEEECCCCCCCCC	16.01	23312004
477	Phosphorylation	AFVIRDSSSYRGSFG CEEEECCCCCCCCCE	35.36	23312004
478	Phosphorylation	FVIRDSSSYRGSFGL EEEECCCCCCCCCEE	23.85	23312004
479	Phosphorylation	VIRDSSSYRGSFGLA EEECCCCCCCCCEEE	22.42	23312004
488	Ubiquitination	GSFGLALKVQEVPAS CCCEEEEEEEECCCC	35.94	-
518	Ubiquitination	FLIESSAKGVHLKGA HHHHHCCCCCCCCCC	64.51	21906983
566	Phosphorylation	LGGADGASDSTDSPA HCCCCCCCCCCCCCH	37.31	23090842
568	Phosphorylation	GADGASDSTDSPASC CCCCCCCCCCCCHHH	31.45	23090842
569	Phosphorylation	ADGASDSTDSPASCQ CCCCCCCCCCCHHHC	45.55	23090842
571	Phosphorylation	GASDSTDSPASCQKK CCCCCCCCCHHHCCC	23.58	25159151
574	Phosphorylation	DSTDSPASCQKKSAG CCCCCCHHHCCCCCC	22.06	23090842
577	Ubiquitination	DSPASCQKKSAGCHT CCCHHHCCCCCCCEE	53.69	21906983
616	Phosphorylation	FERDILPTPTVVHFK CCCCCCCCCEEEEEE	28.31	23312004
618	Phosphorylation	RDILPTPTVVHFKVT CCCCCCCEEEEEEEE	37.32	23312004
625	Phosphorylation	TVVHFKVTEQGITLT EEEEEEEECCCEEEE	24.15	24719451
630	Phosphorylation	KVTEQGITLTDVQRK EEECCCEEEEHHCHH	30.35	24719451
644	Phosphorylation	KVFFRRHYPLTTLRF HHHHHCCCCCCEEEE	9.72	24719451
647	Phosphorylation	FRRHYPLTTLRFCGM HHCCCCCCEEEECCC	21.20	29496963
664	Phosphorylation	EQRKWQKYCKPSWIF HHHHHHHHCCHHHHE	7.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TENS4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TENS4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TENS4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBL_HUMAN	CBL	physical	23774213
GSTCD_HUMAN	GSTCD	physical	25814554
NDKM_HUMAN	NME4	physical	25814554
P4HA2_HUMAN	P4HA2	physical	25814554
P85A_HUMAN	PIK3R1	physical	25814554
RIP_HUMAN	RPAIN	physical	25814554
KCTD4_HUMAN	KCTD4	physical	25814554

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TENS4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82; SER-248; SER-350;SER-404 AND SER-571, AND MASS SPECTROMETRY.	18691976 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-150 AND TYR-284, ANDMASS SPECTROMETRY.	19534553 [Abstract]