TCPR1_HUMAN - dbPTM
TCPR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TCPR1_HUMAN
UniProt AC Q7Z6L1
Protein Name Tectonin beta-propeller repeat-containing protein 1
Gene Name TECPR1
Organism Homo sapiens (Human).
Sequence Length 1165
Subcellular Localization Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.
Protein Description Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation..
Protein Sequence MPNSVLWAVDLFGRVYTLSTAGQYWEMCKDSQLEFKRVSATTQCCWGIACDNQVYVYVCASDVPIRRREEAYENQRWNPMGGFCEKLLLSDRWGWSDVSGLQHRPLDRVALPSPHWEWESDWYVDENFGGEPTEKGGWTYAIDFPATYTKDKKWNSCVRRRKWIRYRRYKSRDIWAKIPSKDDPKELPDPFNDLSVGGWEITEEPVGRLSVWAVSLQGKVWYREDVSHSNPEGSSWSLLDTPGEVVQISCGPHDLLWATLWEGQALVREGINRSNPKGSSWSIVEPPGSENGVMHISVGVSVVWAVTKDWKVWFRRGVNSHNPCGTSWIEMVGEMTMVNVGMNDQVWGIGCEDRAVYFRQGVTPSELSGKTWKAIIAARECDRSHSGSSSSLLSAGCFFGDEVRGSGESAPSDTDASSEVERPGPGQILPAEPLDDSKNATGNSASGLGAGRTAEDTVEDACPAEGSREARPNTHPGPAPTPAELPWTNIDLKEAKKVPSHSAAGFPETTSLSSLGLLPLGLEEPYGVDDHPLWAWVSGGGCVVEACAMPRWFTVQAGLSSSVHMLSLSITPAQTAAWRKQIFQQLTERTKRELENFRHYEQAVEQSVWVKTGALQWWCDWKPHKWVDVRLALEQFTGHDGVRDSILFIYYVVHEEKKYIHIFLNEVVALVPVLNETKHSFALYTPERTRQRWPVRLAAATEQDMNDWLALLSLSCCESRKVQGRPSPQAIWSITCKGDIFVSEPSPDLEAHEHPLPCDQMFWRQMGGHLRMVEANSRGVVWGIGYDHTAWVYTGGYGGGCFQGLASSTSNIYTQSDVKCVHIYENQRWNPVTGYTSRGLPTDRYMWSDASGLQECTKAGTKPPSLQWAWVSDWFVDFSVPGGTDQEGWQYASDFPASYHGSKTMKDFVRRRCWARKCKLVTSGPWLEVPPIALRDVSIIPESPGAEGSGHSIALWAVSDKGDVLCRLGVSELNPAGSSWLHVGTDQPFASISIGACYQVWAVARDGSAFYRGSVYPSQPAGDCWYHIPSPPRQRLKQVSAGQTSVYALDENGNLWYRQGITPSYPQGSSWEHVSNNVCRVSVGPLDQVWVIANKVQGSHSLSRGTVCHRTGVQPHEPKGHGWDYGIGGGWDHISVRANATRAPRSSSQEQEPSAPPEAHGPVCC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
86 (in isoform 4)Ubiquitination-45.69-
86UbiquitinationPMGGFCEKLLLSDRW
CCCCHHHHHHHCCCC		45.69-
140PhosphorylationTEKGGWTYAIDFPAT
CCCCCEEEEEECCCE		8.6118083107
169PhosphorylationKWIRYRRYKSRDIWA
HHHHHCHHCCCCCHH		12.3422210691
171PhosphorylationIRYRRYKSRDIWAKI
HHHCHHCCCCCHHCC		26.6722210691
180PhosphorylationDIWAKIPSKDDPKEL
CCHHCCCCCCCHHHC		52.7924719451
202O-linked_GlycosylationSVGGWEITEEPVGRL
EECCEEECCCCCCCE		23.8430379171
215PhosphorylationRLSVWAVSLQGKVWY
CEEEEEEEECCEEEE		13.76-
301PhosphorylationMHISVGVSVVWAVTK
EEEEEEEEEEEEEEC		12.67-
370 (in isoform 4)Ubiquitination-48.08-
370UbiquitinationTPSELSGKTWKAIIA
CHHHHCCHHHHHHHH		48.08-
373 (in isoform 4)Ubiquitination-34.63-
373UbiquitinationELSGKTWKAIIAARE
HHCCHHHHHHHHHHH		34.63-
384PhosphorylationAARECDRSHSGSSSS
HHHHCCCCCCCCCHH		14.5728450419
386PhosphorylationRECDRSHSGSSSSLL
HHCCCCCCCCCHHHH		41.4328450419
388PhosphorylationCDRSHSGSSSSLLSA
CCCCCCCCCHHHHCC		30.0226657352
389PhosphorylationDRSHSGSSSSLLSAG
CCCCCCCCHHHHCCC		27.7228450419
390PhosphorylationRSHSGSSSSLLSAGC
CCCCCCCHHHHCCCC		27.0528450419
391PhosphorylationSHSGSSSSLLSAGCF
CCCCCCHHHHCCCCC		34.9728450419
394PhosphorylationGSSSSLLSAGCFFGD
CCCHHHHCCCCCCCC		28.1028450419
406PhosphorylationFGDEVRGSGESAPSD
CCCCCCCCCCCCCCC		28.9023403867
409PhosphorylationEVRGSGESAPSDTDA
CCCCCCCCCCCCCCC		49.3423403867
412PhosphorylationGSGESAPSDTDASSE
CCCCCCCCCCCCCCC		53.5126657352
414PhosphorylationGESAPSDTDASSEVE
CCCCCCCCCCCCCCC		37.4926657352
417PhosphorylationAPSDTDASSEVERPG
CCCCCCCCCCCCCCC		29.8223403867
418PhosphorylationPSDTDASSEVERPGP
CCCCCCCCCCCCCCC		47.5926657352
437PhosphorylationPAEPLDDSKNATGNS
CCCCCCCCCCCCCCC		27.7228555341
441PhosphorylationLDDSKNATGNSASGL
CCCCCCCCCCCCCCC		46.41-
444PhosphorylationSKNATGNSASGLGAG
CCCCCCCCCCCCCCC		25.7526471730
446PhosphorylationNATGNSASGLGAGRT
CCCCCCCCCCCCCCC		34.0826471730
488PhosphorylationTPAELPWTNIDLKEA
CCCCCCCCCCCHHHH		21.98-
580UbiquitinationAQTAAWRKQIFQQLT
HHHHHHHHHHHHHHH		36.72-
645PhosphorylationGHDGVRDSILFIYYV
CCCCHHHEEEEEEEE		15.61-
848PhosphorylationPTDRYMWSDASGLQE
CCCCCCCCCCCCHHH		13.5329759185
906UbiquitinationYHGSKTMKDFVRRRC
HCCCHHHHHHHHHHH		53.93-
908 (in isoform 4)Ubiquitination-3.72-
938PhosphorylationPIALRDVSIIPESPG
CEEEEEEEEECCCCC		21.0618669648
943PhosphorylationDVSIIPESPGAEGSG
EEEEECCCCCCCCCC		24.2318669648
949PhosphorylationESPGAEGSGHSIALW
CCCCCCCCCCCEEEE		25.4918669648
1030PhosphorylationDCWYHIPSPPRQRLK
CCCCCCCCCCCHHCE		47.1117081983
1037UbiquitinationSPPRQRLKQVSAGQT
CCCCHHCEECCCCCC		51.33-
1039 (in isoform 4)Ubiquitination-3.96-
1082PhosphorylationSNNVCRVSVGPLDQV
CCCEEEEEEECHHHE		11.2924719451
1101PhosphorylationNKVQGSHSLSRGTVC
EECCCCCCCCCCCCC		29.7224719451
1119UbiquitinationGVQPHEPKGHGWDYG
CCCCCCCCCCCCCCC		61.63-
1121 (in isoform 4)Ubiquitination-40.05-
1146PhosphorylationNATRAPRSSSQEQEP
CCCCCCCCCCCCCCC		33.0328450419
1147PhosphorylationATRAPRSSSQEQEPS
CCCCCCCCCCCCCCC		37.0028450419
1148PhosphorylationTRAPRSSSQEQEPSA
CCCCCCCCCCCCCCC		38.7028450419
1154PhosphorylationSSQEQEPSAPPEAHG
CCCCCCCCCCCCCCC		53.2928450419
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TCPR1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TCPR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TCPR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TPPC8_HUMANTRAPPC8physical
20562859
ATG12_HUMANATG12physical
20562859
ATG5_HUMANATG5physical
20562859
ATG3_HUMANATG3physical
20562859
COIA1_HUMANCOL18A1physical
20562859
TPC11_HUMANTRAPPC11physical
20562859
TPC12_HUMANTRAPPC12physical
20562859
MCMBP_HUMANMCMBPphysical
20562859
PLOD3_HUMANPLOD3physical
20562859
ATG5_HUMANATG5physical
22342342
ATG12_HUMANATG12physical
22342342
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TCPR1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-938; SER-943 ANDSER-949, AND MASS SPECTROMETRY.

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