SV2C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SV2C_HUMAN
• UniProt AC: Q496J9
• Protein Name: Synaptic vesicle glycoprotein 2C
• Gene Name: SV2C
• Organism: Homo sapiens (Human).
• Sequence Length: 727
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like
• Protein Description: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.; (Microbial infection) Receptor for the botulinium neurotoxin type A/BOTA..
• Protein Sequence: MEDSYKDRTSLMKGAKDIAREVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEEDDDDYYPAGETYNGEANDDEGSSEATEGHDEDDEIYEGEYQGIPSMNQAKDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTIKLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDNGRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKSIPILLASTVLVCGGLVGLCLPDTRTQVLM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	VDRAQDEYTQRSYSR HHHHHHHHHHHHHHC	19.23	25884760
75	Phosphorylation	EANDDEGSSEATEGH CCCCCCCCCCCCCCC	23.98	-
76	Phosphorylation	ANDDEGSSEATEGHD CCCCCCCCCCCCCCC	41.95	-
79	Phosphorylation	DEGSSEATEGHDEDD CCCCCCCCCCCCCCC	38.15	-
89	Phosphorylation	HDEDDEIYEGEYQGI CCCCCCCCCCCCCCC	18.81	-
93	Phosphorylation	DEIYEGEYQGIPSMN CCCCCCCCCCCCCHH	23.93	-
108	Phosphorylation	QAKDSIVSVGQPKGD CCCCCEEECCCCCCC	20.89	27499020
113	Ubiquitination	IVSVGQPKGDEYKDR EEECCCCCCCHHHCH	71.72	-
376	Ubiquitination	RARGQPEKVFTVNKI HHCCCCCCEEEECCC	49.70	-
382	Ubiquitination	EKVFTVNKIKTPKQI CCEEEECCCCCHHHH	41.04	-
387	Ubiquitination	VNKIKTPKQIDELIE ECCCCCHHHHHHHEE	66.18	-
466	Phosphorylation	KPLQSDEYALLTRNV CCCCCCCEEEEECCC	13.93	-
480	N-linked_Glycosylation	VERDKYANFTINFTM CCCCCCCCEEEEEEE	31.35	UniProtKB CARBOHYD
484	N-linked_Glycosylation	KYANFTINFTMENQI CCCCEEEEEEECCCC	24.23	UniProtKB CARBOHYD
515	Phosphorylation	KSVTFKDSVFKSCTF EEEEECCCCCCCCCC	30.00	22210691
534	N-linked_Glycosylation	SVNTYFKNCTFIDTV CHHHEECCCCEEEEE	21.84	27313224
559	N-linked_Glycosylation	FIDSEFKNCSFFHNK CCCCCCCCCCCCCCC	31.80	27313224
565	N-linked_Glycosylation	KNCSFFHNKTGCQIT CCCCCCCCCCCCEEE	38.13	27313224
698	Phosphorylation	SLVSITKSIPILLAS HHHHHHCHHHHHHHH	25.58	-
706	Phosphorylation	IPILLASTVLVCGGL HHHHHHHHHHHCCCH	16.55	-
721	Phosphorylation	VGLCLPDTRTQVLM- HHHCCCCCCCCCCC-	33.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SV2C_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SV2C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SV2C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MRP7_HUMAN	ABCC10	physical	28514442
AB17B_HUMAN	ABHD17B	physical	28514442
EXTL3_HUMAN	EXTL3	physical	28514442
VANG2_HUMAN	VANGL2	physical	28514442
UBE4A_HUMAN	UBE4A	physical	28514442
UFD1_HUMAN	UFD1L	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.