| UniProt ID | SUB2_SCHPO | |
|---|---|---|
| UniProt AC | O13792 | |
| Protein Name | ATP-dependent RNA helicase uap56 | |
| Gene Name | uap56 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 434 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC).. | |
| Protein Sequence | MASAQEDLIDYEEEEELVQDQPAQEITPAADTAENGEKSDKKGSYVGIHSTGFRDFLLKPELLRAITDSGFEHPSEVQQVCIPQSILGTDVLCQAKSGMGKTAVFVLSTLQQIEPVDGEVSVLVLCHTRELAFQIKNEYARFSKYLPDVRTAVFYGGINIKQDMEAFKDKSKSPHIVVATPGRLNALVREKILKVNSVKHFVLDECDKLLESVDMRRDIQEVFRATPPQKQVMMFSATLSNEIRPICKKFMQNPLEIYVDDETKLTLHGLQQHYVKLEEKAKNRKINDLLDSLEFNQVVIFVKSVSRANELDRLLRECNFPSICIHGGLPQEERIKRYKAFKDFDKRICVATDVFGRGIDIERVNIVINYDMPDSPDSYLHRVGRAGRFGTKGLAITFSSSEEDSQILDKIQERFEVNITELPDEIDVGSYMNA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASAQEDLID -----CCCCHHHCCC | 29.23 | 29996109 | |
| 27 | Phosphorylation | DQPAQEITPAADTAE CCCCCCCCCCCCCCC | 13.21 | 29996109 | |
| 32 | Phosphorylation | EITPAADTAENGEKS CCCCCCCCCCCCCCC | 31.01 | 29996109 | |
| 44 | Phosphorylation | EKSDKKGSYVGIHST CCCCCCCCEEEEECC | 26.06 | 28889911 | |
| 45 | Phosphorylation | KSDKKGSYVGIHSTG CCCCCCCEEEEECCC | 16.03 | 29996109 | |
| 171 | Phosphorylation | MEAFKDKSKSPHIVV HHHHHCCCCCCCEEE | 48.80 | 25720772 | |
| 173 | Phosphorylation | AFKDKSKSPHIVVAT HHHCCCCCCCEEEEC | 28.89 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SUB2_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SUB2_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SUB2_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MLO3_SCHPO | mlo3 | physical | 15990877 | |
| RAE1_SCHPO | rae1 | physical | 15990877 | |
| TCO89_SCHPO | tco89 | genetic | 22681890 | |
| RPA12_SCHPO | rpa12 | genetic | 22681890 | |
| ATP14_SCHPO | atp14 | genetic | 22681890 | |
| YBJC_SCHPO | red5 | genetic | 23658229 | |
| YCW3_SCHPO | tho1 | physical | 23695164 | |
| SUB2_SCHPO | uap56 | physical | 23695164 | |
| SUB2_SCHPO | uap56 | physical | 26771498 | |
| MSS51_SCHPO | mss51 | physical | 26771498 | |
| YCW3_SCHPO | tho1 | physical | 26771498 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
