| UniProt ID | SIA7C_HUMAN | |
|---|---|---|
| UniProt AC | Q8NDV1 | |
| Protein Name | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | |
| Gene Name | ST6GALNAC3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 305 | |
| Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein . |
|
| Protein Description | Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity).. | |
| Protein Sequence | MACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIPFSYTYRRPLRTHYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKNPDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRVQSGSYLSTGWFTFLLAMDACYGIHVYGMINDTYCKTEGYRKVPYHYYEQGRDECDEYFLHEHAPYGGHRFITEKKVFAKWAKKHRIIFTHPNWTLS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 148 | N-linked_Glycosylation | DYFFKEANTTIYVIW CCEECCCCCEEEEEE | 38.56 | UniProtKB CARBOHYD | |
| 180 | Phosphorylation | LKKTVGIYPNAQIYV HHHHHCCCCCCEEEE | 5.63 | 22817900 | |
| 189 | Phosphorylation | NAQIYVTTEKRMSYC CCEEEEEECCCHHCC | 29.48 | 23879269 | |
| 194 | Phosphorylation | VTTEKRMSYCDGVFK EEECCCHHCCCCEEE | 27.00 | 29083192 | |
| 195 | Phosphorylation | TTEKRMSYCDGVFKK EECCCHHCCCCEEEC | 5.80 | 29083192 | |
| 239 | N-linked_Glycosylation | IHVYGMINDTYCKTE EHHEEEECCCEECCC | 27.04 | UniProtKB CARBOHYD | |
| 301 | N-linked_Glycosylation | RIIFTHPNWTLS--- CEEEECCCCCCC--- | 36.44 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SIA7C_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SIA7C_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SIA7C_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KCC1A_HUMAN | CAMK1 | physical | 26186194 | |
| SAAL1_HUMAN | SAAL1 | physical | 26186194 | |
| SBP1_HUMAN | SELENBP1 | physical | 26186194 | |
| PON2_HUMAN | PON2 | physical | 26186194 | |
| DSG4_HUMAN | DSG4 | physical | 26186194 | |
| PKP3_HUMAN | PKP3 | physical | 26186194 | |
| GGT7_HUMAN | GGT7 | physical | 28514442 | |
| KCC1A_HUMAN | CAMK1 | physical | 28514442 | |
| DSG4_HUMAN | DSG4 | physical | 28514442 | |
| PON2_HUMAN | PON2 | physical | 28514442 | |
| PKP3_HUMAN | PKP3 | physical | 28514442 | |
| DUS14_HUMAN | DUSP14 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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