SGO1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SGO1_DROME
• UniProt AC: Q24141
• Protein Name: Shugoshin
• Gene Name: mei-S332
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 401
• Subcellular Localization: Chromosome, centromere . Localizes to the centromere of meiotic and mitotic chromosomes (PubMed:9490715, PubMed:10654079). During meiosis, it assembles onto centromeres during prometaphase I, remains attached until anaphase II, during which it is dis
• Protein Description: Plays a central role in chromosome cohesion during meiosis and mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting or Rad21 from cleavage by Sse/separase. Required during meiosis in both males and females..
• Protein Sequence: MGSKVEQQYKLLNAELMDQVQKQRLEIGEYRKRVISLEREIMDIREEHVLQNHRQRMENISIVRSLMLSLNVDSDSLAVRQEPAPAAQINRPSGPRRSSREICKDMRRTCALARTTRPISPRRSSSVTSTVSSTSRRSSAEVQSEVVTTRIPEDRRANKPTPPPRRPAELVFDEDDSDDDFDEAVSPVEETQTEQNEENNRLFSIIEENGSEGESTDSSSSCEAIYCDTTFESSPPNAQVTVTPSGRALREVDTNIPVAVSLSRGKETGKGSWLAISVAVEDSPQEPSIQCPRLAVTRPSQSSGIFPDVNGLTPRRSLFNGIGKMAGSTSTPKSFLVEEMPSIRTRSRTAANKKSENTDMSSSFCNNSARPSRSCRPTSLVEPSLKNKLRNGSKGKAKAKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Acetylation	----MGSKVEQQYKL ----CCCHHHHHHHH	44.02	21791702
98	Phosphorylation	RPSGPRRSSREICKD CCCCCCCCHHHHHHH	34.72	22817900
99	Phosphorylation	PSGPRRSSREICKDM CCCCCCCHHHHHHHH	31.92	22817900
120	Phosphorylation	ARTTRPISPRRSSSV HHCCCCCCCCCCCCC	18.29	25749252
124	Phosphorylation	RPISPRRSSSVTSTV CCCCCCCCCCCCEEC	28.39	-
125	Phosphorylation	PISPRRSSSVTSTVS CCCCCCCCCCCEECC	27.32	-
126	Phosphorylation	ISPRRSSSVTSTVSS CCCCCCCCCCEECCC	30.57	-
161	Phosphorylation	DRRANKPTPPPRRPA HHHCCCCCCCCCCCC	50.46	22817900
303	Phosphorylation	VTRPSQSSGIFPDVN EECCCCCCCCCCCCC	28.42	21082442
331	Phosphorylation	KMAGSTSTPKSFLVE CCCCCCCCCHHHHHH	34.52	16824953

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
124	S	Phosphorylation	Kinase	AURB	Q9VKN7	Uniprot
125	S	Phosphorylation	Kinase	AURB	Q9VKN7	Uniprot
126	S	Phosphorylation	Kinase	AURB	Q9VKN7	Uniprot
331	T	Phosphorylation	Kinase	PLK1	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SGO1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SGO1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYSP1_DROME	Prm	physical	14605208
MYSP2_DROME	Prm	physical	14605208
TULP_DROME	ktub	physical	14605208
ANX11_DROME	AnxB11	physical	14605208
POLO_DROME	polo	genetic	15621529
2AAA_DROME	Pp2A-29B	physical	17306545
2AAA_DROME	Pp2A-29B	physical	19475384
SGO1_DROME	mei-S332	physical	9869638
PP2A_DROME	mts	physical	17306545
PP2A_DROME	mts	physical	19475384
2ABA_DROME	tws	physical	17306545

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.