SEM7A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEM7A_HUMAN
• UniProt AC: O75326
• Protein Name: Semaphorin-7A
• Gene Name: SEMA7A
• Organism: Homo sapiens (Human).
• Sequence Length: 666
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor ; Extracellular side . Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
• Protein Description: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes..
• Protein Sequence: MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSCLDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDKVFRTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCGWDQGRCISIYSSERSVLQSINPAEPHKECPNPKPDKAPLQKVSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEGSYFREAQHWQLLPEDGIMAEHLLGHACALAASLWLGVLPTLTLGLLVH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	N-linked_Glycosylation	FDFPEGKNASVRTVN EECCCCCCCEEEEEE	48.59	20727575
135	Asymmetric dimethylarginine	NYITLLERRSEGLLA HHHHHHHHHCCCCEE	47.60	-
135	Methylation	NYITLLERRSEGLLA HHHHHHHHHCCCCEE	47.60	-
157	N-linked_Glycosylation	PSCWNLVNGTVVPLG CHHHHCCCCEEEECC	43.51	20727575
258	N-linked_Glycosylation	KNPEAPLNVSRVAQL CCCCCCCCHHHHHHH	28.76	20727575
258	N-linked_Glycosylation	KNPEAPLNVSRVAQL CCCCCCCCHHHHHHH	28.76	20727575
275	Phosphorylation	GDQGGESSLSVSKWN CCCCCCCCCCHHHHH	21.99	-
277	Phosphorylation	QGGESSLSVSKWNTF CCCCCCCCHHHHHHH	26.71	24719451
292	Phosphorylation	LKAMLVCSDAATNKN HHHHHHCCHHHCCCC	23.86	-
296	Phosphorylation	LVCSDAATNKNFNRL HHCCHHHCCCCCCCC	48.74	-
313	Phosphorylation	VFLLPDPSGQWRDTR EEEEECCCCCCCCEE	51.50	-
330	N-linked_Glycosylation	GVFSNPWNYSAVCVY EEECCCCCEEEEEEE	23.34	20727575
375	O-linked_Glycosylation	PDQQPIPTETFQVAD CCCCCCCCCCEEHHH	48.67	OGP
602	N-linked_Glycosylation	NCILFIENLTAQQYG CEEEEEECCCHHHHC	37.56	10201933
648	GPI-anchor	LGHACALAASLWLGV HHHHHHHHHHHHHCH	4.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEM7A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEM7A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEM7A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOAT1_HUMAN	SOAT1	physical	28514442
D19L1_HUMAN	DPY19L1	physical	28514442
UN93B_HUMAN	UNC93B1	physical	28514442
TAPT1_HUMAN	TAPT1	physical	28514442
TM214_HUMAN	TMEM214	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
TM39B_HUMAN	TMEM39B	physical	28514442
SL9A1_HUMAN	SLC9A1	physical	28514442
S12A9_HUMAN	SLC12A9	physical	28514442
AT11C_HUMAN	ATP11C	physical	28514442
LMF2_HUMAN	LMF2	physical	28514442
SGPL1_HUMAN	SGPL1	physical	28514442
CLCC1_HUMAN	CLCC1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Structural basis of semaphorin-plexin recognition and viral mimicryfrom Sema7A and A39R complexes with PlexinC1.";
Liu H., Juo Z.S., Shim A.H., Focia P.J., Chen X., Garcia K.C., He X.;
Cell 142:749-761(2010).
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 45-634 IN COMPLEX WITHPLXNC1, SUBUNIT, DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-105;ASN-157; ASN-258 AND ASN-330.
PubMed: 20727575