| UniProt ID | RPGF4_HUMAN | |
|---|---|---|
| UniProt AC | Q8WZA2 | |
| Protein Name | Rap guanine nucleotide exchange factor 4 | |
| Gene Name | RAPGEF4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1011 | |
| Subcellular Localization |
Cytoplasm. Membrane Peripheral membrane protein. |
|
| Protein Description | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).. | |
| Protein Sequence | MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 116 | Phosphorylation | IGTAFGESILDNTPR CCHHHCHHHHCCCCC | 28.91 | 17081983 | |
| 121 | Phosphorylation | GESILDNTPRHATIV CHHHHCCCCCCEEEE | 22.74 | - | |
| 150 | Phosphorylation | FKALWEKYRQYMAGL HHHHHHHHHHHHHHH | 7.45 | - | |
| 153 | Phosphorylation | LWEKYRQYMAGLLAP HHHHHHHHHHHHCCC | 4.67 | - | |
| 216 | Phosphorylation | ILRNAILSRAPHMIR HHHHHHHHCCCHHHC | 21.93 | - | |
| 284 | Phosphorylation | EHHFQDKYLFYRFLD CHHCCCCCHHHCCCC | 15.44 | 29449344 | |
| 287 | Phosphorylation | FQDKYLFYRFLDDEH CCCCCHHHCCCCCCC | 9.62 | 29449344 | |
| 301 | Phosphorylation | HEDAPLPTEEEKKEC CCCCCCCCHHHHHHC | 64.81 | 29449344 | |
| 320 | Phosphorylation | QDTMLLLSQMGPDAH HHHHHHHHHHCCCHH | 20.35 | 24043423 | |
| 464 | Phosphorylation | LRDVEANTVRLKEHD HHHHHHCEEECCCCC | 17.66 | 22985185 | |
| 492 | Phosphorylation | RASNQGNSQPQQKYT CCCCCCCCCCCHHEE | 50.49 | 29116813 | |
| 497 | Ubiquitination | GNSQPQQKYTVMSGT CCCCCCHHEEECCCC | 37.33 | - | |
| 499 | Phosphorylation | SQPQQKYTVMSGTPE CCCCHHEEECCCCHH | 19.44 | 29116813 | |
| 502 | Phosphorylation | QQKYTVMSGTPEKIL CHHEEECCCCHHHHH | 34.87 | 29116813 | |
| 504 | Phosphorylation | KYTVMSGTPEKILEH HEEECCCCHHHHHHH | 22.44 | 29116813 | |
| 645 | Acetylation | KAPQKKHKVLLQQFN CCCHHHHHHHHHHCC | 43.38 | 20167786 | |
| 667 | Phosphorylation | KRQPIRGSDEVLFKV HHCCCCCCCCEEEEE | 22.28 | 22985185 | |
| 809 | Phosphorylation | GRHNFKKTTANLDLF CCCCCCCCCCCHHHH | 31.56 | - | |
| 810 | Phosphorylation | RHNFKKTTANLDLFL CCCCCCCCCCHHHHH | 23.56 | - | |
| 857 | Phosphorylation | IAAHCKEYKNLNSFF HHHHHHHCCCHHHHH | 7.23 | - | |
| 887 | Phosphorylation | LTWEKLPSKFKKFYA HCHHHCCHHHHHHHH | 62.25 | 24719451 | |
| 932 | Phosphorylation | PLLIKDMTFTHEGNK HEEEECCEEEECCCC | 35.20 | 22210691 | |
| 986 | Phosphorylation | NHQDVRSYVRQLNVI CHHHHHHHHHHHHHH | 6.78 | - | |
| 998 | Phosphorylation | NVIDNQRTLSQMSHR HHHCCCHHHHHHHHC | 22.46 | 22199227 | |
| 1000 | Phosphorylation | IDNQRTLSQMSHRLE HCCCHHHHHHHHCCC | 24.19 | 22199227 | |
| 1003 | Phosphorylation | QRTLSQMSHRLEPRR CHHHHHHHHCCCCCC | 9.60 | 22199227 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RPGF4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPGF4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPGF4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RAP2A_HUMAN | RAP2A | physical | 10777494 | |
| RAP1A_HUMAN | RAP1A | physical | 10777494 | |
| RIMS2_HUMAN | RIMS2 | physical | 11598134 | |
| RIMB1_HUMAN | BZRAP1 | physical | 24722188 | |
| SWP70_HUMAN | SWAP70 | physical | 24722188 | |
| TRAF2_HUMAN | TRAF2 | physical | 24722188 | |
| ZC11A_HUMAN | ZC3H11A | physical | 24722188 | |
| CP045_HUMAN | C16orf45 | physical | 24722188 | |
| CP045_HUMAN | C16orf45 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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